QFR measurements post CTO percutaneous coronary intervention: Can the long term outcome be predicted?
Background: QFR, a non-invasive tool using 3D coronary artery imaging and fluid dynamics, helps assess revascularization benefits in patients with coronary chronic total occlusion (CTO). Methods and Results: A retrospective study of 616 CTO patients who underwent PCI for CTO, with QFR assessed post-...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
|
| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000922 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850038878148231168 |
|---|---|
| author | Yanguo Xin Jiayu Li Xiaosong Ding Xuhe Gong Li Zhou Hui Chen |
| author_facet | Yanguo Xin Jiayu Li Xiaosong Ding Xuhe Gong Li Zhou Hui Chen |
| author_sort | Yanguo Xin |
| collection | DOAJ |
| description | Background: QFR, a non-invasive tool using 3D coronary artery imaging and fluid dynamics, helps assess revascularization benefits in patients with coronary chronic total occlusion (CTO). Methods and Results: A retrospective study of 616 CTO patients who underwent PCI for CTO, with QFR assessed post-procedure. In a 5-year follow-up study involving 616 patients, the study used three tertiles (first tertile: QFR ≥ 0.88, second tertile: 0.85 ≤ QFR < 0.88, third tertile: QFR < 0.85) to determine the “cut-off” value. QFR showed strong predictive power with an area under the curve (AUC) of 0.80 (95 % confidence interval: 0.77–0.83, P < 0.001). The occurrence of MACCEs among all participants in the study was 28.4 %. This rate varied across different groups, with 63.9 % in the low QFR tertile, 14.8 % in the middle tertile, and 12.6 % in the high QFR group. During the follow-up period, a variation in the occurrence of MACCEs was observed among the three groups (P < 0.05). Analysis using Kaplan-Meier curves indicated a statistically major difference in the cumulative rates of MACCEs across the groups. Competing risk regression analysis indicated that QFR is negatively associated with all-cause mortality, cardiovascular mortality, and composite MACCEs. Conclusion: The study found a high prognostic value of physiological assessment using QFR after successful CTO intervention. |
| format | Article |
| id | doaj-art-1672ffa4ff384879ab45a18f6b37587f |
| institution | DOAJ |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-1672ffa4ff384879ab45a18f6b37587f2025-08-20T02:56:29ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-08-015910168910.1016/j.ijcha.2025.101689QFR measurements post CTO percutaneous coronary intervention: Can the long term outcome be predicted?Yanguo Xin0Jiayu Li1Xiaosong Ding2Xuhe Gong3Li Zhou4Hui Chen5Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaCorresponding authors at: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, No.95 Yong’an Road, Xicheng District, Beijing 100050, China.; Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaCorresponding authors at: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, No.95 Yong’an Road, Xicheng District, Beijing 100050, China.; Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaBackground: QFR, a non-invasive tool using 3D coronary artery imaging and fluid dynamics, helps assess revascularization benefits in patients with coronary chronic total occlusion (CTO). Methods and Results: A retrospective study of 616 CTO patients who underwent PCI for CTO, with QFR assessed post-procedure. In a 5-year follow-up study involving 616 patients, the study used three tertiles (first tertile: QFR ≥ 0.88, second tertile: 0.85 ≤ QFR < 0.88, third tertile: QFR < 0.85) to determine the “cut-off” value. QFR showed strong predictive power with an area under the curve (AUC) of 0.80 (95 % confidence interval: 0.77–0.83, P < 0.001). The occurrence of MACCEs among all participants in the study was 28.4 %. This rate varied across different groups, with 63.9 % in the low QFR tertile, 14.8 % in the middle tertile, and 12.6 % in the high QFR group. During the follow-up period, a variation in the occurrence of MACCEs was observed among the three groups (P < 0.05). Analysis using Kaplan-Meier curves indicated a statistically major difference in the cumulative rates of MACCEs across the groups. Competing risk regression analysis indicated that QFR is negatively associated with all-cause mortality, cardiovascular mortality, and composite MACCEs. Conclusion: The study found a high prognostic value of physiological assessment using QFR after successful CTO intervention.http://www.sciencedirect.com/science/article/pii/S2352906725000922Coronary chronic total occlusionPercutaneous coronary interventionQuantitative flow ratioMajor adverse cardiac and cerebral events |
| spellingShingle | Yanguo Xin Jiayu Li Xiaosong Ding Xuhe Gong Li Zhou Hui Chen QFR measurements post CTO percutaneous coronary intervention: Can the long term outcome be predicted? International Journal of Cardiology: Heart & Vasculature Coronary chronic total occlusion Percutaneous coronary intervention Quantitative flow ratio Major adverse cardiac and cerebral events |
| title | QFR measurements post CTO percutaneous coronary intervention: Can the long term outcome be predicted? |
| title_full | QFR measurements post CTO percutaneous coronary intervention: Can the long term outcome be predicted? |
| title_fullStr | QFR measurements post CTO percutaneous coronary intervention: Can the long term outcome be predicted? |
| title_full_unstemmed | QFR measurements post CTO percutaneous coronary intervention: Can the long term outcome be predicted? |
| title_short | QFR measurements post CTO percutaneous coronary intervention: Can the long term outcome be predicted? |
| title_sort | qfr measurements post cto percutaneous coronary intervention can the long term outcome be predicted |
| topic | Coronary chronic total occlusion Percutaneous coronary intervention Quantitative flow ratio Major adverse cardiac and cerebral events |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000922 |
| work_keys_str_mv | AT yanguoxin qfrmeasurementspostctopercutaneouscoronaryinterventioncanthelongtermoutcomebepredicted AT jiayuli qfrmeasurementspostctopercutaneouscoronaryinterventioncanthelongtermoutcomebepredicted AT xiaosongding qfrmeasurementspostctopercutaneouscoronaryinterventioncanthelongtermoutcomebepredicted AT xuhegong qfrmeasurementspostctopercutaneouscoronaryinterventioncanthelongtermoutcomebepredicted AT lizhou qfrmeasurementspostctopercutaneouscoronaryinterventioncanthelongtermoutcomebepredicted AT huichen qfrmeasurementspostctopercutaneouscoronaryinterventioncanthelongtermoutcomebepredicted |