E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration
The ubiquitination-proteasome system (UPS) is crucial in regulating a variety of cellular processes including proliferation, differentiation, and survival. Ubiquitin protein ligase E3 is the most critical molecule in the UPS system. Dysregulation of the UPS system is associated with many conditions....
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/6948367 |
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| _version_ | 1832548797018800128 |
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| author | Ruiyin Zeng Yuan Xiong Ze Lin Adriana C. Panayi Yun Sun Faqi Cao Guohui Liu |
| author_facet | Ruiyin Zeng Yuan Xiong Ze Lin Adriana C. Panayi Yun Sun Faqi Cao Guohui Liu |
| author_sort | Ruiyin Zeng |
| collection | DOAJ |
| description | The ubiquitination-proteasome system (UPS) is crucial in regulating a variety of cellular processes including proliferation, differentiation, and survival. Ubiquitin protein ligase E3 is the most critical molecule in the UPS system. Dysregulation of the UPS system is associated with many conditions. Over the past few decades, there have been an increasing number of studies focusing on the UPS system and how it affects bone metabolism. Multiple E3 ubiquitin ligases have been found to mediate osteogenesis or osteolysis through a variety of pathways. In this review, we describe the mechanisms of UPS, especially E3 ubiquitin ligases on bone metabolism. To date, many E3 ubiquitin ligases have been found to regulate osteogenesis or osteoclast differentiation. We review the classification of these E3 enzymes and the mechanisms that influence upstream and downstream molecules and transduction pathways. Finally, this paper reviews the discovery of the relevant UPS inhibitors, drug molecules, and noncoding RNAs so far and prospects the future research and treatment. |
| format | Article |
| id | doaj-art-166abcc0c3b143ed8eee459804d646fb |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-166abcc0c3b143ed8eee459804d646fb2025-02-03T06:13:01ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/6948367E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and DegenerationRuiyin Zeng0Yuan Xiong1Ze Lin2Adriana C. Panayi3Yun Sun4Faqi Cao5Guohui Liu6Department of OrthopaedicsDepartment of OrthopaedicsDepartment of OrthopaedicsDivision of Plastic SurgeryHubei Province Key Laboratory of Oral and Maxillofacial Development and RegenerationDepartment of OrthopaedicsDepartment of OrthopaedicsThe ubiquitination-proteasome system (UPS) is crucial in regulating a variety of cellular processes including proliferation, differentiation, and survival. Ubiquitin protein ligase E3 is the most critical molecule in the UPS system. Dysregulation of the UPS system is associated with many conditions. Over the past few decades, there have been an increasing number of studies focusing on the UPS system and how it affects bone metabolism. Multiple E3 ubiquitin ligases have been found to mediate osteogenesis or osteolysis through a variety of pathways. In this review, we describe the mechanisms of UPS, especially E3 ubiquitin ligases on bone metabolism. To date, many E3 ubiquitin ligases have been found to regulate osteogenesis or osteoclast differentiation. We review the classification of these E3 enzymes and the mechanisms that influence upstream and downstream molecules and transduction pathways. Finally, this paper reviews the discovery of the relevant UPS inhibitors, drug molecules, and noncoding RNAs so far and prospects the future research and treatment.http://dx.doi.org/10.1155/2022/6948367 |
| spellingShingle | Ruiyin Zeng Yuan Xiong Ze Lin Adriana C. Panayi Yun Sun Faqi Cao Guohui Liu E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration Stem Cells International |
| title | E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration |
| title_full | E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration |
| title_fullStr | E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration |
| title_full_unstemmed | E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration |
| title_short | E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration |
| title_sort | e3 ubiquitin ligases potential therapeutic targets for skeletal pathology and degeneration |
| url | http://dx.doi.org/10.1155/2022/6948367 |
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