Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism
Methylene blue (MB) is a promising photosensitizer (PS) for the treatment of pathological neoplasms, since it has both photodynamic activity (under laser irradiation) and redox and catalytic properties (in the absence of light). In the framework of this work, using spectroscopic methods, the effect...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2023-05-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/578 |
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| author | D. V. Pominova A. V. Ryabova A. S. Skobeltsin I. V. Markova I. D. Romanishkin V. B. Loschenov |
| author_facet | D. V. Pominova A. V. Ryabova A. S. Skobeltsin I. V. Markova I. D. Romanishkin V. B. Loschenov |
| author_sort | D. V. Pominova |
| collection | DOAJ |
| description | Methylene blue (MB) is a promising photosensitizer (PS) for the treatment of pathological neoplasms, since it has both photodynamic activity (under laser irradiation) and redox and catalytic properties (in the absence of light). In the framework of this work, using spectroscopic methods, the effect of intravenous administration of MB on tissue oxygenation of hemoglobin in small animals in vivo in tumor and normal tissues was analyzed. The influence of MB on cell metabolism was analyzed. It has been shown that the use of MB promotes an increase in oxygen consumption by the tumor, and also leads to a shift in metabolism towards oxidative phosphorylation. It was shown that the use of MB contributes to an increase in oxygen consumption by the tumor, and also leads to a shift in metabolism towards oxidative phosphorylation. |
| format | Article |
| id | doaj-art-16684960c6094049bae204a1f64b60e4 |
| institution | Kabale University |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-16684960c6094049bae204a1f64b60e42025-08-20T03:35:29ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322023-05-0112141310.24931/2413-9432-2023-12-1-4-13267Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolismD. V. Pominova0A. V. Ryabova1A. S. Skobeltsin2I. V. Markova3I. D. Romanishkin4V. B. Loschenov5Prokhorov General Physics Institute of Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Prokhorov General Physics Institute of Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Prokhorov General Physics Institute of Russian Academy of SciencesNational Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Prokhorov General Physics Institute of Russian Academy of SciencesProkhorov General Physics Institute of Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Methylene blue (MB) is a promising photosensitizer (PS) for the treatment of pathological neoplasms, since it has both photodynamic activity (under laser irradiation) and redox and catalytic properties (in the absence of light). In the framework of this work, using spectroscopic methods, the effect of intravenous administration of MB on tissue oxygenation of hemoglobin in small animals in vivo in tumor and normal tissues was analyzed. The influence of MB on cell metabolism was analyzed. It has been shown that the use of MB promotes an increase in oxygen consumption by the tumor, and also leads to a shift in metabolism towards oxidative phosphorylation. It was shown that the use of MB contributes to an increase in oxygen consumption by the tumor, and also leads to a shift in metabolism towards oxidative phosphorylation.https://www.pdt-journal.com/jour/article/view/578methylene blueoxygenationtumor metabolism |
| spellingShingle | D. V. Pominova A. V. Ryabova A. S. Skobeltsin I. V. Markova I. D. Romanishkin V. B. Loschenov Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism Biomedical Photonics methylene blue oxygenation tumor metabolism |
| title | Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism |
| title_full | Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism |
| title_fullStr | Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism |
| title_full_unstemmed | Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism |
| title_short | Spectroscopic study of methylene blue in vivo: effects on tissue oxygenation and tumor metabolism |
| title_sort | spectroscopic study of methylene blue in vivo effects on tissue oxygenation and tumor metabolism |
| topic | methylene blue oxygenation tumor metabolism |
| url | https://www.pdt-journal.com/jour/article/view/578 |
| work_keys_str_mv | AT dvpominova spectroscopicstudyofmethyleneblueinvivoeffectsontissueoxygenationandtumormetabolism AT avryabova spectroscopicstudyofmethyleneblueinvivoeffectsontissueoxygenationandtumormetabolism AT asskobeltsin spectroscopicstudyofmethyleneblueinvivoeffectsontissueoxygenationandtumormetabolism AT ivmarkova spectroscopicstudyofmethyleneblueinvivoeffectsontissueoxygenationandtumormetabolism AT idromanishkin spectroscopicstudyofmethyleneblueinvivoeffectsontissueoxygenationandtumormetabolism AT vbloschenov spectroscopicstudyofmethyleneblueinvivoeffectsontissueoxygenationandtumormetabolism |