Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.
The first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early li...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044763&type=printable |
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| author | Brian A Reikie Rozanne C M Adams Candice E Ruck Kevin Ho Aleksandra Leligdowicz Santoshan Pillay Shalena Naidoo Edgardo S Fortuno Corena de Beer Wolfgang Preiser Mark F Cotton David P Speert Monika Esser Tobias R Kollmann |
| author_facet | Brian A Reikie Rozanne C M Adams Candice E Ruck Kevin Ho Aleksandra Leligdowicz Santoshan Pillay Shalena Naidoo Edgardo S Fortuno Corena de Beer Wolfgang Preiser Mark F Cotton David P Speert Monika Esser Tobias R Kollmann |
| author_sort | Brian A Reikie |
| collection | DOAJ |
| description | The first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early life may be due to less effective innate immune function. In this study, we followed a longitudinal cohort of infants born and raised in South Africa over the first year of life, employing the most comprehensive analysis of innate immune response to stimulation published to date. Our findings reveal rapid changes in innate immune development over the first year of life. This is the first report depicting dramatic differences in innate immune ontogeny between different populations in the world, with important implications for global vaccination strategies. |
| format | Article |
| id | doaj-art-1663c057c8e44cf18262958cdbfa26ae |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-1663c057c8e44cf18262958cdbfa26ae2025-08-20T02:05:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4476310.1371/journal.pone.0044763Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.Brian A ReikieRozanne C M AdamsCandice E RuckKevin HoAleksandra LeligdowiczSantoshan PillayShalena NaidooEdgardo S FortunoCorena de BeerWolfgang PreiserMark F CottonDavid P SpeertMonika EsserTobias R KollmannThe first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early life may be due to less effective innate immune function. In this study, we followed a longitudinal cohort of infants born and raised in South Africa over the first year of life, employing the most comprehensive analysis of innate immune response to stimulation published to date. Our findings reveal rapid changes in innate immune development over the first year of life. This is the first report depicting dramatic differences in innate immune ontogeny between different populations in the world, with important implications for global vaccination strategies.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044763&type=printable |
| spellingShingle | Brian A Reikie Rozanne C M Adams Candice E Ruck Kevin Ho Aleksandra Leligdowicz Santoshan Pillay Shalena Naidoo Edgardo S Fortuno Corena de Beer Wolfgang Preiser Mark F Cotton David P Speert Monika Esser Tobias R Kollmann Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS ONE |
| title | Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. |
| title_full | Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. |
| title_fullStr | Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. |
| title_full_unstemmed | Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. |
| title_short | Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. |
| title_sort | ontogeny of toll like receptor mediated cytokine responses of south african infants throughout the first year of life |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044763&type=printable |
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