Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective study
Objective: The large body of literature examining the association between parenthood and mortality in the general population contrasts with a lack of such studies on older adults with schizophrenia. Identifying potential protective factors of premature death in this population is important to help...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Psiquiatria (ABP)
2025-05-01
|
| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462025000100214&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850128726134620160 |
|---|---|
| author | Katayoun Rezaei Sandra Abou Kassm María Sofía Garcés-González Marina Sánchez-Rico Mark Olfson Charles Ouazana-Vedrines Valentin Scheer Mahdi Fayad Pierre Meneton Frédéric Limosin Nicolas Hoertel |
| author_facet | Katayoun Rezaei Sandra Abou Kassm María Sofía Garcés-González Marina Sánchez-Rico Mark Olfson Charles Ouazana-Vedrines Valentin Scheer Mahdi Fayad Pierre Meneton Frédéric Limosin Nicolas Hoertel |
| author_sort | Katayoun Rezaei |
| collection | DOAJ |
| description | Objective: The large body of literature examining the association between parenthood and mortality in the general population contrasts with a lack of such studies on older adults with schizophrenia. Identifying potential protective factors of premature death in this population is important to help guide prevention measures. Here, we examined whether all-cause and cause-specific mortality rates significantly differ between older parents and non-parents with schizophrenia during a 5-year follow-up. Methods: We used data from a 5-year prospective multicenter sample of older adults with an ICD-10 diagnosis of schizophrenia (aged 55 years or more) recruited in France. We performed a forward stepwise logistic regression to examine the association between parenthood and all-cause mortality, including only independent variables that best explain outcome. Results: Of the 323 older adults with schizophrenia, 133 (41.2%) were parents (mean age = 67.0, SD = 6.1) and 190 were not (mean age = 67.2, SD = 6.6). Following adjustments, parenthood was significantly associated with lower all-cause mortality compared to patients without children (21.1% [n=28] vs. 35.8% [n=68]; AOR = 0.50; 95%CI 0.27-0.94; p = 0.032); the association involved no significant sex differences. Conclusion: Parenthood could be a protective factor against mortality among older patients with schizophrenia who live in France. Further research is needed to understand the specific mechanisms underlying this association. |
| format | Article |
| id | doaj-art-165e9d773c0a4f178901ca7215587c5d |
| institution | OA Journals |
| issn | 1809-452X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj-art-165e9d773c0a4f178901ca7215587c5d2025-08-20T02:33:12ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2025-05-014710.47626/1516-4446-2024-3731Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective studyKatayoun Rezaeihttps://orcid.org/0000-0003-2309-4794Sandra Abou KassmMaría Sofía Garcés-GonzálezMarina Sánchez-RicoMark OlfsonCharles Ouazana-VedrinesValentin ScheerMahdi FayadPierre MenetonFrédéric LimosinNicolas Hoertelhttps://orcid.org/0000-0002-7890-1349 Objective: The large body of literature examining the association between parenthood and mortality in the general population contrasts with a lack of such studies on older adults with schizophrenia. Identifying potential protective factors of premature death in this population is important to help guide prevention measures. Here, we examined whether all-cause and cause-specific mortality rates significantly differ between older parents and non-parents with schizophrenia during a 5-year follow-up. Methods: We used data from a 5-year prospective multicenter sample of older adults with an ICD-10 diagnosis of schizophrenia (aged 55 years or more) recruited in France. We performed a forward stepwise logistic regression to examine the association between parenthood and all-cause mortality, including only independent variables that best explain outcome. Results: Of the 323 older adults with schizophrenia, 133 (41.2%) were parents (mean age = 67.0, SD = 6.1) and 190 were not (mean age = 67.2, SD = 6.6). Following adjustments, parenthood was significantly associated with lower all-cause mortality compared to patients without children (21.1% [n=28] vs. 35.8% [n=68]; AOR = 0.50; 95%CI 0.27-0.94; p = 0.032); the association involved no significant sex differences. Conclusion: Parenthood could be a protective factor against mortality among older patients with schizophrenia who live in France. Further research is needed to understand the specific mechanisms underlying this association.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462025000100214&lng=en&tlng=enParenthoodchildrenschizophreniamortalityolder adults |
| spellingShingle | Katayoun Rezaei Sandra Abou Kassm María Sofía Garcés-González Marina Sánchez-Rico Mark Olfson Charles Ouazana-Vedrines Valentin Scheer Mahdi Fayad Pierre Meneton Frédéric Limosin Nicolas Hoertel Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective study Brazilian Journal of Psychiatry Parenthood children schizophrenia mortality older adults |
| title | Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective study |
| title_full | Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective study |
| title_fullStr | Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective study |
| title_full_unstemmed | Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective study |
| title_short | Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective study |
| title_sort | parenthood and all cause mortality in older adults with schizophrenia a multicenter 5 year prospective study |
| topic | Parenthood children schizophrenia mortality older adults |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462025000100214&lng=en&tlng=en |
| work_keys_str_mv | AT katayounrezaei parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT sandraaboukassm parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT mariasofiagarcesgonzalez parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT marinasanchezrico parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT markolfson parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT charlesouazanavedrines parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT valentinscheer parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT mahdifayad parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT pierremeneton parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT fredericlimosin parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy AT nicolashoertel parenthoodandallcausemortalityinolderadultswithschizophreniaamulticenter5yearprospectivestudy |