Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases
Peroxisome proliferator-activated receptor γ (PPAR γ), a member of the nuclear receptor superfamily, is a ligand-activated transcription factor that plays an important role in the control of a variety of physiological processes. The last decade has witnessed an increasing interest for the role playe...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/275435 |
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| _version_ | 1850234611547766784 |
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| author | Su Zhang Hongwei Gu Nan Hu |
| author_facet | Su Zhang Hongwei Gu Nan Hu |
| author_sort | Su Zhang |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor γ (PPAR γ), a member of the nuclear receptor superfamily, is a ligand-activated transcription factor that plays an important role in the control of a variety of physiological processes. The last decade has witnessed an increasing interest for the role played by the agonists of PPAR γ in antiangiogenesis, antifibrosis, anti-inflammation effects and in controlling oxidative stress response in various organs. As the pathologic mechanisms of major blinding diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), keratitis, and optic neuropathy, often involve neoangiogenesis and inflammation- and oxidative stress-mediated cell death, evidences are accumulating on the potential benefits of PPAR γ to improve or prevent these vision threatening eye diseases. In this paper we describe what is known about the role of PPAR γ in the ocular pathophysiological processes and PPAR γ agonists as novel adjuvants in the treatment of eye diseases. |
| format | Article |
| id | doaj-art-165a05c5c85644e18f260391cb4e8a89 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-165a05c5c85644e18f260391cb4e8a892025-08-20T02:02:34ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/275435275435Role of Peroxisome Proliferator-Activated Receptor γ in Ocular DiseasesSu Zhang0Hongwei Gu1Nan Hu2Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, ChinaDepartment of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, ChinaDepartment of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, ChinaPeroxisome proliferator-activated receptor γ (PPAR γ), a member of the nuclear receptor superfamily, is a ligand-activated transcription factor that plays an important role in the control of a variety of physiological processes. The last decade has witnessed an increasing interest for the role played by the agonists of PPAR γ in antiangiogenesis, antifibrosis, anti-inflammation effects and in controlling oxidative stress response in various organs. As the pathologic mechanisms of major blinding diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), keratitis, and optic neuropathy, often involve neoangiogenesis and inflammation- and oxidative stress-mediated cell death, evidences are accumulating on the potential benefits of PPAR γ to improve or prevent these vision threatening eye diseases. In this paper we describe what is known about the role of PPAR γ in the ocular pathophysiological processes and PPAR γ agonists as novel adjuvants in the treatment of eye diseases.http://dx.doi.org/10.1155/2015/275435 |
| spellingShingle | Su Zhang Hongwei Gu Nan Hu Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases Journal of Ophthalmology |
| title | Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases |
| title_full | Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases |
| title_fullStr | Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases |
| title_full_unstemmed | Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases |
| title_short | Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases |
| title_sort | role of peroxisome proliferator activated receptor γ in ocular diseases |
| url | http://dx.doi.org/10.1155/2015/275435 |
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