Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients
Rheumatoid arthritis (RA) is a systematic autoimmune disorder with chronic inflammation changes of unknown etiology. Various synovial inflammatory and proliferative alterations may contribute to the cartilaginous tissues and invasive bony tissues, leading to destructive joints and malformed bones. Thi...
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University of Baghdad, College of Science for Women
2021-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5362 |
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| author | Firas Faris Rija Sura Zahim Hussein Mohammad Ahmad Abdalla |
| author_facet | Firas Faris Rija Sura Zahim Hussein Mohammad Ahmad Abdalla |
| author_sort | Firas Faris Rija |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a systematic autoimmune disorder with chronic inflammation changes of unknown etiology. Various synovial inflammatory and proliferative alterations may contribute to the cartilaginous tissues and invasive bony tissues, leading to destructive joints and malformed bones. This disease is mostly due to infective microorganisms or genetic susceptibility causing immune system disturbances through triggering both T-cells and B-cells. Furthermore, different immune cells may secret cytokines, which are responsible for some RA pathogenesis activity. From ninety individuals, serum sample was collected; thirty of them were normal and sixty cases were patients with RA attended a privet medical clinic at Tikrit city from May 2019 to November 2019. Age, in both patients and control groups, ranged between (18-50) years, they had assay of Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Tumor necrosis factor (TNF)-α, Leptin, Adiponectin, and C-reactive protein. The present study shows that (IL-1, Leptin, and CRP) levels were higher in Rheumatoid Arthritis patients than control, while (IL-6, IL-10, TNFα, and ADP) levels were lower; therefore, cytokines can play an essential role in RA pathogenesis. The current study may bring attention to adiponectin and leptin for their roles in the pathogenesis of RA. Special consideration was devoted to those proteins, which act on cells associated with RA, also for possible usage of these protein levels as potential biomarkers for the disease activity and therapeutic response. |
| format | Article |
| id | doaj-art-16535cbff95e41ae8f8da999db952b7d |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-16535cbff95e41ae8f8da999db952b7d2025-08-20T03:15:54ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862021-06-0118210.21123/bsj.2021.18.2.0247Physiological and Immunological Disturbance in Rheumatoid Arthritis PatientsFiras Faris Rija0Sura Zahim Hussein1Mohammad Ahmad Abdalla2Tikrit University College of Sciences / Biology DepartmentSalah Aldeen Health Directorate / Clinical Biochemistry UnitTikrit University College of MedicineRheumatoid arthritis (RA) is a systematic autoimmune disorder with chronic inflammation changes of unknown etiology. Various synovial inflammatory and proliferative alterations may contribute to the cartilaginous tissues and invasive bony tissues, leading to destructive joints and malformed bones. This disease is mostly due to infective microorganisms or genetic susceptibility causing immune system disturbances through triggering both T-cells and B-cells. Furthermore, different immune cells may secret cytokines, which are responsible for some RA pathogenesis activity. From ninety individuals, serum sample was collected; thirty of them were normal and sixty cases were patients with RA attended a privet medical clinic at Tikrit city from May 2019 to November 2019. Age, in both patients and control groups, ranged between (18-50) years, they had assay of Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Tumor necrosis factor (TNF)-α, Leptin, Adiponectin, and C-reactive protein. The present study shows that (IL-1, Leptin, and CRP) levels were higher in Rheumatoid Arthritis patients than control, while (IL-6, IL-10, TNFα, and ADP) levels were lower; therefore, cytokines can play an essential role in RA pathogenesis. The current study may bring attention to adiponectin and leptin for their roles in the pathogenesis of RA. Special consideration was devoted to those proteins, which act on cells associated with RA, also for possible usage of these protein levels as potential biomarkers for the disease activity and therapeutic response.https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5362Interleukins, TNF α, Leptin, CRP, Adiponectin |
| spellingShingle | Firas Faris Rija Sura Zahim Hussein Mohammad Ahmad Abdalla Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients مجلة بغداد للعلوم Interleukins, TNF α, Leptin, CRP, Adiponectin |
| title | Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients |
| title_full | Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients |
| title_fullStr | Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients |
| title_full_unstemmed | Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients |
| title_short | Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients |
| title_sort | physiological and immunological disturbance in rheumatoid arthritis patients |
| topic | Interleukins, TNF α, Leptin, CRP, Adiponectin |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/5362 |
| work_keys_str_mv | AT firasfarisrija physiologicalandimmunologicaldisturbanceinrheumatoidarthritispatients AT surazahimhussein physiologicalandimmunologicaldisturbanceinrheumatoidarthritispatients AT mohammadahmadabdalla physiologicalandimmunologicaldisturbanceinrheumatoidarthritispatients |