Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic Gingivostomatitis
The cat oral microbiome plays an important role in maintaining host health, yet little is known about how to apply microbial data in a clinical setting. One such use of microbiome signatures is in cases of feline chronic gingivostomatitis (FCGS), a severe debilitating complex disease of the oral cav...
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2025-01-01
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| author | Claire A. Shaw Maria Soltero-Rivera Rodrigo Profeta Bart C. Weimer |
| author_facet | Claire A. Shaw Maria Soltero-Rivera Rodrigo Profeta Bart C. Weimer |
| author_sort | Claire A. Shaw |
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| description | The cat oral microbiome plays an important role in maintaining host health, yet little is known about how to apply microbial data in a clinical setting. One such use of microbiome signatures is in cases of feline chronic gingivostomatitis (FCGS), a severe debilitating complex disease of the oral cavity. FCGS-afflicted cats have limited treatment options, and individual patient responses to treatment are needed. In this work, we used deep sequencing of total RNA of the oral microbiome to chronicle microbial changes that accompanied an FCGS-afflicted cat’s change from treatment-non-responsive to treatment-responsive within a 17-month span. The oral microbiome composition of the two treatment-non-responsive time points differed from that of the treatment-responsive point, with notable shifts in the abundance of <i>Myscoplasmopsis</i>, <i>Aspergillus</i>, and <i>Capnocytophaga</i> species. Intriguingly, the presence of the fungal groups <i>Aspergillus</i> and <i>Candida</i> primarily differentiated the two non-responsive microbiomes. Associated with responder status were multiple <i>Capnocytophaga</i> species, including <i>Capnocytophaga</i> sp. H2931, <i>Capnocytophaga gingivalis</i>, and <i>Capnocytophaga canimorsus</i>. The observation that the oral microbiome shifts in tandem by response to treatment in FCGS suggests a potential use for microbiome evaluations in a clinical setting. This work contributes to developing improved molecular diagnostics for enhanced efficacy of individualized treatment plans to improve oral disease. |
| format | Article |
| id | doaj-art-164bf3e022014e4b8c80213314a01cfe |
| institution | DOAJ |
| issn | 2674-1334 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-164bf3e022014e4b8c80213314a01cfe2025-08-20T02:42:38ZengMDPI AGBacteria2674-13342025-01-0141110.3390/bacteria4010001Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic GingivostomatitisClaire A. Shaw0Maria Soltero-Rivera1Rodrigo Profeta2Bart C. Weimer3Department of Population Health and Reproduction, 100K Pathogen Genome Project, University of California, Davis, CA 95616, USADepartment of Surgical and Radiological Sciences, University of California, Davis, CA 95616, USADepartment of Population Health and Reproduction, 100K Pathogen Genome Project, University of California, Davis, CA 95616, USADepartment of Population Health and Reproduction, 100K Pathogen Genome Project, University of California, Davis, CA 95616, USAThe cat oral microbiome plays an important role in maintaining host health, yet little is known about how to apply microbial data in a clinical setting. One such use of microbiome signatures is in cases of feline chronic gingivostomatitis (FCGS), a severe debilitating complex disease of the oral cavity. FCGS-afflicted cats have limited treatment options, and individual patient responses to treatment are needed. In this work, we used deep sequencing of total RNA of the oral microbiome to chronicle microbial changes that accompanied an FCGS-afflicted cat’s change from treatment-non-responsive to treatment-responsive within a 17-month span. The oral microbiome composition of the two treatment-non-responsive time points differed from that of the treatment-responsive point, with notable shifts in the abundance of <i>Myscoplasmopsis</i>, <i>Aspergillus</i>, and <i>Capnocytophaga</i> species. Intriguingly, the presence of the fungal groups <i>Aspergillus</i> and <i>Candida</i> primarily differentiated the two non-responsive microbiomes. Associated with responder status were multiple <i>Capnocytophaga</i> species, including <i>Capnocytophaga</i> sp. H2931, <i>Capnocytophaga gingivalis</i>, and <i>Capnocytophaga canimorsus</i>. The observation that the oral microbiome shifts in tandem by response to treatment in FCGS suggests a potential use for microbiome evaluations in a clinical setting. This work contributes to developing improved molecular diagnostics for enhanced efficacy of individualized treatment plans to improve oral disease.https://www.mdpi.com/2674-1334/4/1/1feline chronic gingivostomatitismetagenomicsoral microbiome |
| spellingShingle | Claire A. Shaw Maria Soltero-Rivera Rodrigo Profeta Bart C. Weimer Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic Gingivostomatitis Bacteria feline chronic gingivostomatitis metagenomics oral microbiome |
| title | Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic Gingivostomatitis |
| title_full | Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic Gingivostomatitis |
| title_fullStr | Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic Gingivostomatitis |
| title_full_unstemmed | Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic Gingivostomatitis |
| title_short | Case Report: Inflammation-Driven Species-Level Shifts in the Oral Microbiome of Refractory Feline Chronic Gingivostomatitis |
| title_sort | case report inflammation driven species level shifts in the oral microbiome of refractory feline chronic gingivostomatitis |
| topic | feline chronic gingivostomatitis metagenomics oral microbiome |
| url | https://www.mdpi.com/2674-1334/4/1/1 |
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