Immunogenic Targets for Specific Immunotherapy in Multiple Myeloma
Multiple myeloma remains an incurable disease although the prognosis has been improved by novel therapeutics and agents recently. Relapse occurs in the majority of patients and becomes fatal finally. Immunotherapy might be a powerful intervention to maintain a long-lasting control of minimal residua...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/820394 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549977412337664 |
|---|---|
| author | Lu Zhang Marlies Götz Susanne Hofmann Jochen Greiner |
| author_facet | Lu Zhang Marlies Götz Susanne Hofmann Jochen Greiner |
| author_sort | Lu Zhang |
| collection | DOAJ |
| description | Multiple myeloma remains an incurable disease although the prognosis has been improved by novel therapeutics and agents recently. Relapse occurs in the majority of patients and becomes fatal finally. Immunotherapy might be a powerful intervention to maintain a long-lasting control of minimal residual disease or to even eradicate disseminated tumor cells. Several tumor-associated antigens have been identified in patients with multiple myeloma. These antigens are expressed in a tumor-specific or tumor-restricted pattern, are able to elicit immune response, and thus could serve as targets for immunotherapy. This review discusses immunogenic antigens with therapeutic potential for multiple myeloma. |
| format | Article |
| id | doaj-art-164b41873344483693856ff4d233c397 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-164b41873344483693856ff4d233c3972025-02-03T06:07:55ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/820394820394Immunogenic Targets for Specific Immunotherapy in Multiple MyelomaLu Zhang0Marlies Götz1Susanne Hofmann2Jochen Greiner3Department of Internal Medicine III, University of Ulm, 89081 Ulm, GermanyDepartment of Internal Medicine III, University of Ulm, 89081 Ulm, GermanyDepartment of Internal Medicine III, University of Ulm, 89081 Ulm, GermanyDepartment of Internal Medicine III, University of Ulm, 89081 Ulm, GermanyMultiple myeloma remains an incurable disease although the prognosis has been improved by novel therapeutics and agents recently. Relapse occurs in the majority of patients and becomes fatal finally. Immunotherapy might be a powerful intervention to maintain a long-lasting control of minimal residual disease or to even eradicate disseminated tumor cells. Several tumor-associated antigens have been identified in patients with multiple myeloma. These antigens are expressed in a tumor-specific or tumor-restricted pattern, are able to elicit immune response, and thus could serve as targets for immunotherapy. This review discusses immunogenic antigens with therapeutic potential for multiple myeloma.http://dx.doi.org/10.1155/2012/820394 |
| spellingShingle | Lu Zhang Marlies Götz Susanne Hofmann Jochen Greiner Immunogenic Targets for Specific Immunotherapy in Multiple Myeloma Clinical and Developmental Immunology |
| title | Immunogenic Targets for Specific Immunotherapy in Multiple Myeloma |
| title_full | Immunogenic Targets for Specific Immunotherapy in Multiple Myeloma |
| title_fullStr | Immunogenic Targets for Specific Immunotherapy in Multiple Myeloma |
| title_full_unstemmed | Immunogenic Targets for Specific Immunotherapy in Multiple Myeloma |
| title_short | Immunogenic Targets for Specific Immunotherapy in Multiple Myeloma |
| title_sort | immunogenic targets for specific immunotherapy in multiple myeloma |
| url | http://dx.doi.org/10.1155/2012/820394 |
| work_keys_str_mv | AT luzhang immunogenictargetsforspecificimmunotherapyinmultiplemyeloma AT marliesgotz immunogenictargetsforspecificimmunotherapyinmultiplemyeloma AT susannehofmann immunogenictargetsforspecificimmunotherapyinmultiplemyeloma AT jochengreiner immunogenictargetsforspecificimmunotherapyinmultiplemyeloma |