PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms

PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms

Summary: Cisplatin (CDDP) is a widely used chemotherapy drug for treating various solid tumors. However, resistance to CDDP significantly hampers patient outcomes. This study reveals that protein arginine methyltransferase (PRMT)5 methylates METTL3 at the R36 residue (METTL3-R36me2), which is crucia...

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Bibliographic Details
Main Authors: Qiaoxi Xia, Ronghui Zhong, Jingfang Zheng, Xiao Zhou, Xinwei Zhao, Sisi Wang, Botao Wang, Quanfeng Wu, Chen Xie, Beihua Kong, Qing Zhang, Tianzhi Huang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725002554
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