Protective effects of L-Carnitine and kiwifruit extract against benzo[a]pyrene-induced testicular toxicity in Sprague-Dawley rats
Objective: Benzo[a]pyrene (BaP) is a widespread environmental pollutant known to impair testicular structure and function. This study evaluates whether L-carnitine and kiwifruit extract can protect against BaP-induced testicular toxicity in adult male albino rats. Methods: Forty adult male albino...
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Babcock Medical Society
2025-06-01
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| Series: | Babcock University Medical Journal |
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| Online Access: | https://bumj.babcock.edu.ng/index.php/bumj/article/view/907 |
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| author | MM Nawaf LH Ali Nafi Saud |
| author_facet | MM Nawaf LH Ali Nafi Saud |
| author_sort | MM Nawaf |
| collection | DOAJ |
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Objective: Benzo[a]pyrene (BaP) is a widespread environmental pollutant known to impair testicular structure and function. This study evaluates whether L-carnitine and kiwifruit extract can protect against BaP-induced testicular toxicity in adult male albino rats.
Methods: Forty adult male albino rats (160–225 g) were randomly divided into five groups (n=8 each): control (corn oil), BaP (10 mg/kg), BaP plus L-carnitine (200 mg/kg), BaP plus kiwifruit extract (500 mg/kg), and BaP plus combined treatment. Treatments were administered three times per week for 90 days. Serum testosterone, FSH, and glutathione peroxidase (GPX) activities, as well as malondialdehyde (MDA), IL-1β, and TNF-α levels, were measured. Testicular histology was examined by H&E staining.
Results: Benzo[a]pyrene exposure significantly decreased Testosterone, FSH, and GPX levels and increased MDA, IL-1β, and TNFα levels compared to the control group (p < 0.05). L-carnitine and kiwifruit treatments ameliorated these changes, while combined therapy showed less marked improvement. Histological evaluation revealed severe testicular damage in the Benzo[a]pyrene group, with notable recovery in groups treated with either L-carnitine or kiwifruit, particularly the latter.
Conclusion: Kiwifruit extract confers stronger protection than L-carnitine against BaP-induced testicular toxicity; combined therapy does not yield additional benefit.
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| format | Article |
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| institution | DOAJ |
| issn | 2465-6666 2756-4657 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Babcock Medical Society |
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| series | Babcock University Medical Journal |
| spelling | doaj-art-1641f059fbcf4554902b65c82f4e64bf2025-08-20T03:15:47ZengBabcock Medical SocietyBabcock University Medical Journal2465-66662756-46572025-06-018110.38029/babcockuniv.med.j..v8i1.907Protective effects of L-Carnitine and kiwifruit extract against benzo[a]pyrene-induced testicular toxicity in Sprague-Dawley ratsMM Nawaf0LH Ali1Nafi Saud2Department of Biology, College of Education for Pure Sciences, University of Anbar, Ramadi, Anbar 31001, IraqDepartment of Biology, College of Education for Pure Sciences, University of Anbar, Ramadi, Anbar 31001, IraqDepartment of Biology, College of Education for Pure Sciences, University of Anbar, Ramadi, Anbar 31001, Iraq Objective: Benzo[a]pyrene (BaP) is a widespread environmental pollutant known to impair testicular structure and function. This study evaluates whether L-carnitine and kiwifruit extract can protect against BaP-induced testicular toxicity in adult male albino rats. Methods: Forty adult male albino rats (160–225 g) were randomly divided into five groups (n=8 each): control (corn oil), BaP (10 mg/kg), BaP plus L-carnitine (200 mg/kg), BaP plus kiwifruit extract (500 mg/kg), and BaP plus combined treatment. Treatments were administered three times per week for 90 days. Serum testosterone, FSH, and glutathione peroxidase (GPX) activities, as well as malondialdehyde (MDA), IL-1β, and TNF-α levels, were measured. Testicular histology was examined by H&E staining. Results: Benzo[a]pyrene exposure significantly decreased Testosterone, FSH, and GPX levels and increased MDA, IL-1β, and TNFα levels compared to the control group (p < 0.05). L-carnitine and kiwifruit treatments ameliorated these changes, while combined therapy showed less marked improvement. Histological evaluation revealed severe testicular damage in the Benzo[a]pyrene group, with notable recovery in groups treated with either L-carnitine or kiwifruit, particularly the latter. Conclusion: Kiwifruit extract confers stronger protection than L-carnitine against BaP-induced testicular toxicity; combined therapy does not yield additional benefit. https://bumj.babcock.edu.ng/index.php/bumj/article/view/907Benzo[a]pyreneVitamin CWistar ratsOxidative stressToxic effectsInflammation |
| spellingShingle | MM Nawaf LH Ali Nafi Saud Protective effects of L-Carnitine and kiwifruit extract against benzo[a]pyrene-induced testicular toxicity in Sprague-Dawley rats Babcock University Medical Journal Benzo[a]pyrene Vitamin C Wistar rats Oxidative stress Toxic effects Inflammation |
| title | Protective effects of L-Carnitine and kiwifruit extract against benzo[a]pyrene-induced testicular toxicity in Sprague-Dawley rats |
| title_full | Protective effects of L-Carnitine and kiwifruit extract against benzo[a]pyrene-induced testicular toxicity in Sprague-Dawley rats |
| title_fullStr | Protective effects of L-Carnitine and kiwifruit extract against benzo[a]pyrene-induced testicular toxicity in Sprague-Dawley rats |
| title_full_unstemmed | Protective effects of L-Carnitine and kiwifruit extract against benzo[a]pyrene-induced testicular toxicity in Sprague-Dawley rats |
| title_short | Protective effects of L-Carnitine and kiwifruit extract against benzo[a]pyrene-induced testicular toxicity in Sprague-Dawley rats |
| title_sort | protective effects of l carnitine and kiwifruit extract against benzo a pyrene induced testicular toxicity in sprague dawley rats |
| topic | Benzo[a]pyrene Vitamin C Wistar rats Oxidative stress Toxic effects Inflammation |
| url | https://bumj.babcock.edu.ng/index.php/bumj/article/view/907 |
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