Antiepileptic activity and potential mechanism of full-spectrum hemp extract
Epilepsy is the fourth most common neuropsychiatric disorder. Although the approval of Epidiolex has ignited hope for patients, there is still a large gap in the field of anti-seizure research. The effect and underlying mechanism of full-spectrum hemp extract (HE) remains unclear. Here this study in...
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824004552 |
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| author | Zengliang Jin Zhuo Huang |
| author_facet | Zengliang Jin Zhuo Huang |
| author_sort | Zengliang Jin |
| collection | DOAJ |
| description | Epilepsy is the fourth most common neuropsychiatric disorder. Although the approval of Epidiolex has ignited hope for patients, there is still a large gap in the field of anti-seizure research. The effect and underlying mechanism of full-spectrum hemp extract (HE) remains unclear. Here this study investigated the anti-seizure effect of HE on seizure models. The results showed that HE significantly reduced seizure susceptibility and prolonged seizure latency with better pharmacokinetic performance compared to CBD. This article then further explored the anti-seizure active components and their possible mechanism in HE. The results indicated that cannabichromene (CBC) and cannabinol (CBN) were involved in the anti-seizure process, especially CBC showed a strong allosteric enhancement effects on CBD binding site of the GABAA receptor, which implied that the GABAA receptor seemed to be the primary anti-epileptic target of HE. This article not only presents the great potential of HE as a candidate for new anti-epileptic drugs with less psychoactive, but also provides a valuable contribution to subsequent mechanism research and drug development on epilepsy.Abstract: Epilepsy is the fourth most coneuropsychiatric disorder. Although the approval of Epidiolex has ignited hope for patients, there is still a large gap in the field of anti-seizure research. The effect and underlying mechanism of full-spectrum hemp extract remains unclear. Here this study investigated the anti-seizure effect of HE on seizure models. The results showed that HE significantly reduced seizure susceptibility and prolonged seizure latency with better pharmacokinetic performance compared to CBD. This article then further explored the anti-seizure active components and their possible mechanism in HE. The results indicated that cannabichromene and cannabinol were involved in the anti-seizure process, especially CBC showed a strong allosteric enhancement effects on CBD binding site of the GABAA receptor, which implied that the GABAA receptor seemed to be the primary anti-epileptic target of HE. This article not only presents the great potential of HE as a candidate for new anti-epileptic drugs with less psychoactive, but also provides a valuable contribution to subsequent mechanism research and drug development on epilepsy. |
| format | Article |
| id | doaj-art-163f9880bb8b4b7a95eedf462dd5588b |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-163f9880bb8b4b7a95eedf462dd5588b2025-01-29T05:02:38ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-0151379380Antiepileptic activity and potential mechanism of full-spectrum hemp extractZengliang Jin0Zhuo Huang1Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Corresponding author.State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Health Science Center, Beijing 100191, China; IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, ChinaEpilepsy is the fourth most common neuropsychiatric disorder. Although the approval of Epidiolex has ignited hope for patients, there is still a large gap in the field of anti-seizure research. The effect and underlying mechanism of full-spectrum hemp extract (HE) remains unclear. Here this study investigated the anti-seizure effect of HE on seizure models. The results showed that HE significantly reduced seizure susceptibility and prolonged seizure latency with better pharmacokinetic performance compared to CBD. This article then further explored the anti-seizure active components and their possible mechanism in HE. The results indicated that cannabichromene (CBC) and cannabinol (CBN) were involved in the anti-seizure process, especially CBC showed a strong allosteric enhancement effects on CBD binding site of the GABAA receptor, which implied that the GABAA receptor seemed to be the primary anti-epileptic target of HE. This article not only presents the great potential of HE as a candidate for new anti-epileptic drugs with less psychoactive, but also provides a valuable contribution to subsequent mechanism research and drug development on epilepsy.Abstract: Epilepsy is the fourth most coneuropsychiatric disorder. Although the approval of Epidiolex has ignited hope for patients, there is still a large gap in the field of anti-seizure research. The effect and underlying mechanism of full-spectrum hemp extract remains unclear. Here this study investigated the anti-seizure effect of HE on seizure models. The results showed that HE significantly reduced seizure susceptibility and prolonged seizure latency with better pharmacokinetic performance compared to CBD. This article then further explored the anti-seizure active components and their possible mechanism in HE. The results indicated that cannabichromene and cannabinol were involved in the anti-seizure process, especially CBC showed a strong allosteric enhancement effects on CBD binding site of the GABAA receptor, which implied that the GABAA receptor seemed to be the primary anti-epileptic target of HE. This article not only presents the great potential of HE as a candidate for new anti-epileptic drugs with less psychoactive, but also provides a valuable contribution to subsequent mechanism research and drug development on epilepsy.http://www.sciencedirect.com/science/article/pii/S2667325824004552HempCannabinoidsPharmacokineticsAnti-seizure drugsGABAA receptor |
| spellingShingle | Zengliang Jin Zhuo Huang Antiepileptic activity and potential mechanism of full-spectrum hemp extract Fundamental Research Hemp Cannabinoids Pharmacokinetics Anti-seizure drugs GABAA receptor |
| title | Antiepileptic activity and potential mechanism of full-spectrum hemp extract |
| title_full | Antiepileptic activity and potential mechanism of full-spectrum hemp extract |
| title_fullStr | Antiepileptic activity and potential mechanism of full-spectrum hemp extract |
| title_full_unstemmed | Antiepileptic activity and potential mechanism of full-spectrum hemp extract |
| title_short | Antiepileptic activity and potential mechanism of full-spectrum hemp extract |
| title_sort | antiepileptic activity and potential mechanism of full spectrum hemp extract |
| topic | Hemp Cannabinoids Pharmacokinetics Anti-seizure drugs GABAA receptor |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824004552 |
| work_keys_str_mv | AT zengliangjin antiepilepticactivityandpotentialmechanismoffullspectrumhempextract AT zhuohuang antiepilepticactivityandpotentialmechanismoffullspectrumhempextract |