Ambient low-level benzene, genetic factors, and heart failure incidence among urban adults
Ambient benzene, a representative volatile organic compound (VOC) primarily resulting from rapid industrialization and urbanization, is also of great concern as an urban air toxic. The global benzene market is experiencing steady growth, driven by its use in industrial manufacturing. Currently, popu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325005433 |
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| author | Yongxuan Li Yujia Bao Jiawei Gu Zheshen Han Xiaobei Deng Wei Mu Hui Wang Hongchao Qi Lefei Han Jinjun Ran |
| author_facet | Yongxuan Li Yujia Bao Jiawei Gu Zheshen Han Xiaobei Deng Wei Mu Hui Wang Hongchao Qi Lefei Han Jinjun Ran |
| author_sort | Yongxuan Li |
| collection | DOAJ |
| description | Ambient benzene, a representative volatile organic compound (VOC) primarily resulting from rapid industrialization and urbanization, is also of great concern as an urban air toxic. The global benzene market is experiencing steady growth, driven by its use in industrial manufacturing. Currently, population epidemiological evidence about the effects of ambient benzene on heart failure (HF) incidence is still inadequate, especially at low levels of long-term exposure. Leveraging data from 277,585 urban residents in the UK Biobank, the study utilized Cox regression models adjusted for potential confounders to evaluate the association between low-concentration benzene exposure and HF risk. The investigation also assessed potential interactions between genetic predisposition and ambient benzene by applying relative excess risk due to interaction (RERI) metrics and interaction significance testing. Furthermore, the effect of ambient benzene on cardiac functional parameters was estimated using multiple linear regression models. This study demonstrated that per interquartile range increment of ambient benzene was related to the elevated HF risk (hazard ratios = 1.22, 95 % confidence interval (CI): 1.07–1.39] from the time-dependent Cox model. An additive interaction between ambient benzene and genetic risk was observed (RERI = 0.18, 95 % CI: 0.01–0.36). Ambient benzene exposure demonstrated significant correlations with modifications in cardiac functional parameters, such as ventricular end-diastolic and end-systolic volumes. Prolonged exposure to low-concentration ambient benzene may elevate the likelihood of developing HF, which provides the necessary evidence for the systematic risk assessment of ambient benzene and promotes the formulation and updating of air quality guidelines worldwide. |
| format | Article |
| id | doaj-art-163d3602ea53446c9478a764a2166f9c |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-163d3602ea53446c9478a764a2166f9c2025-08-20T03:14:02ZengElsevierEcotoxicology and Environmental Safety0147-65132025-05-0129611820710.1016/j.ecoenv.2025.118207Ambient low-level benzene, genetic factors, and heart failure incidence among urban adultsYongxuan Li0Yujia Bao1Jiawei Gu2Zheshen Han3Xiaobei Deng4Wei Mu5Hui Wang6Hongchao Qi7Lefei Han8Jinjun Ran9School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, University of Hong Kong, Hong KongSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children’s Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UKSchool of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, 412 West No. 1 Bldg, 280 South Chongqing Rd, Shanghai 200025, China.School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: School of Public Health, Shanghai Jiao Tong University School of Medicine, 413 East No. 1 Bldg, 227 South Chongqing Rd, Shanghai 200025, China.Ambient benzene, a representative volatile organic compound (VOC) primarily resulting from rapid industrialization and urbanization, is also of great concern as an urban air toxic. The global benzene market is experiencing steady growth, driven by its use in industrial manufacturing. Currently, population epidemiological evidence about the effects of ambient benzene on heart failure (HF) incidence is still inadequate, especially at low levels of long-term exposure. Leveraging data from 277,585 urban residents in the UK Biobank, the study utilized Cox regression models adjusted for potential confounders to evaluate the association between low-concentration benzene exposure and HF risk. The investigation also assessed potential interactions between genetic predisposition and ambient benzene by applying relative excess risk due to interaction (RERI) metrics and interaction significance testing. Furthermore, the effect of ambient benzene on cardiac functional parameters was estimated using multiple linear regression models. This study demonstrated that per interquartile range increment of ambient benzene was related to the elevated HF risk (hazard ratios = 1.22, 95 % confidence interval (CI): 1.07–1.39] from the time-dependent Cox model. An additive interaction between ambient benzene and genetic risk was observed (RERI = 0.18, 95 % CI: 0.01–0.36). Ambient benzene exposure demonstrated significant correlations with modifications in cardiac functional parameters, such as ventricular end-diastolic and end-systolic volumes. Prolonged exposure to low-concentration ambient benzene may elevate the likelihood of developing HF, which provides the necessary evidence for the systematic risk assessment of ambient benzene and promotes the formulation and updating of air quality guidelines worldwide.http://www.sciencedirect.com/science/article/pii/S0147651325005433Urban air toxicAmbient benzeneHeart failureCardiac structureUrban health |
| spellingShingle | Yongxuan Li Yujia Bao Jiawei Gu Zheshen Han Xiaobei Deng Wei Mu Hui Wang Hongchao Qi Lefei Han Jinjun Ran Ambient low-level benzene, genetic factors, and heart failure incidence among urban adults Ecotoxicology and Environmental Safety Urban air toxic Ambient benzene Heart failure Cardiac structure Urban health |
| title | Ambient low-level benzene, genetic factors, and heart failure incidence among urban adults |
| title_full | Ambient low-level benzene, genetic factors, and heart failure incidence among urban adults |
| title_fullStr | Ambient low-level benzene, genetic factors, and heart failure incidence among urban adults |
| title_full_unstemmed | Ambient low-level benzene, genetic factors, and heart failure incidence among urban adults |
| title_short | Ambient low-level benzene, genetic factors, and heart failure incidence among urban adults |
| title_sort | ambient low level benzene genetic factors and heart failure incidence among urban adults |
| topic | Urban air toxic Ambient benzene Heart failure Cardiac structure Urban health |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325005433 |
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