Synthesis of new derivatives of protoporphyrin IX
In the course of searching new highly active substances which are prospective for treating tumors and some other types of widespread diseases the synthesis of protoporphyrin IX bearing the benzodiazepine residue, was performed. It was found that the use of porphyrins containing acetylacetonate resid...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2010-10-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/935 |
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| author | V. Yu. Pavlov А. Е. Stepanov V. I. Shvets |
| author_facet | V. Yu. Pavlov А. Е. Stepanov V. I. Shvets |
| author_sort | V. Yu. Pavlov |
| collection | DOAJ |
| description | In the course of searching new highly active substances which are prospective for treating tumors and some other types of widespread diseases the synthesis of protoporphyrin IX bearing the benzodiazepine residue, was performed. It was found that the use of porphyrins containing acetylacetonate residues in the heterocyclic synthesis leads to ketone splitting of the acetylacetonate moiety under the mild conditions of regioselective synthesis of benzodiazepine in addition to the formation of porphyrin-benzodiazepines. |
| format | Article |
| id | doaj-art-163c2be510e54150b8ef38ce10a2d980 |
| institution | DOAJ |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2010-10-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-163c2be510e54150b8ef38ce10a2d9802025-08-20T03:23:19ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752010-10-01558287929Synthesis of new derivatives of protoporphyrin IXV. Yu. Pavlov0А. Е. Stepanov1V. I. Shvets2M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571In the course of searching new highly active substances which are prospective for treating tumors and some other types of widespread diseases the synthesis of protoporphyrin IX bearing the benzodiazepine residue, was performed. It was found that the use of porphyrins containing acetylacetonate residues in the heterocyclic synthesis leads to ketone splitting of the acetylacetonate moiety under the mild conditions of regioselective synthesis of benzodiazepine in addition to the formation of porphyrin-benzodiazepines.https://www.finechem-mirea.ru/jour/article/view/935protoporphyrin ixphotodynamic therapyphotosensitizer |
| spellingShingle | V. Yu. Pavlov А. Е. Stepanov V. I. Shvets Synthesis of new derivatives of protoporphyrin IX Тонкие химические технологии protoporphyrin ix photodynamic therapy photosensitizer |
| title | Synthesis of new derivatives of protoporphyrin IX |
| title_full | Synthesis of new derivatives of protoporphyrin IX |
| title_fullStr | Synthesis of new derivatives of protoporphyrin IX |
| title_full_unstemmed | Synthesis of new derivatives of protoporphyrin IX |
| title_short | Synthesis of new derivatives of protoporphyrin IX |
| title_sort | synthesis of new derivatives of protoporphyrin ix |
| topic | protoporphyrin ix photodynamic therapy photosensitizer |
| url | https://www.finechem-mirea.ru/jour/article/view/935 |
| work_keys_str_mv | AT vyupavlov synthesisofnewderivativesofprotoporphyrinix AT aestepanov synthesisofnewderivativesofprotoporphyrinix AT vishvets synthesisofnewderivativesofprotoporphyrinix |