Aberrant origin of left vertebral artery: A molecular embryological perspective
Background: Variation in the origin and course of the left vertebral artery have surgical and clinical implications in the management of medical conditions. Here, we show variant origin of the left vertebral artery in cadavers and propose potential causes for future molecular investigations. Method:...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Translational Research in Anatomy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214854X25000408 |
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| author | Connor Lee McCoy John Joseph Cichewicz Rainevan Miller Soumya Sharma Adel Maklad Eistine Boateng |
| author_facet | Connor Lee McCoy John Joseph Cichewicz Rainevan Miller Soumya Sharma Adel Maklad Eistine Boateng |
| author_sort | Connor Lee McCoy |
| collection | DOAJ |
| description | Background: Variation in the origin and course of the left vertebral artery have surgical and clinical implications in the management of medical conditions. Here, we show variant origin of the left vertebral artery in cadavers and propose potential causes for future molecular investigations. Method: The aortic arches of 32 donors were dissected and observed for anomalous origin of the left vertebral artery in the cadaver laboratory at the University of Toledo, Ohio, USA. Results: Out of 32 donors dissected during laboratory sessions, we observed two cases of the left vertebral artery originating directly from the aortic arch, medial to the left subclavian artery. Conclusion: The study aims to stimulate discussions and future investigations into the molecular embryology of vasculogenesis concomitant with preconceptional and in utero exposures to understand the underlying causes of aberrant origin of the left vertebral artery. Additionally, we speculate that parental and embryonic environmental exposures influence the epigenetic landscape in germ cells and early embryos, thereby contributing to the programming of variant origin of blood vessels. |
| format | Article |
| id | doaj-art-16315ceddecb46288fef8e4e69d631bf |
| institution | Kabale University |
| issn | 2214-854X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Research in Anatomy |
| spelling | doaj-art-16315ceddecb46288fef8e4e69d631bf2025-08-21T04:16:58ZengElsevierTranslational Research in Anatomy2214-854X2025-09-014010042110.1016/j.tria.2025.100421Aberrant origin of left vertebral artery: A molecular embryological perspectiveConnor Lee McCoy0John Joseph Cichewicz1Rainevan Miller2Soumya Sharma3Adel Maklad4Eistine Boateng5College of Medicine and Life Sciences, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USACollege of Medicine and Life Sciences, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USACollege of Medicine and Life Sciences, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USA; Corresponding author.College of Medicine and Life Sciences, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USACollege of Medicine and Life Sciences, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USA; Department of Medical Education, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USACollege of Medicine and Life Sciences, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USA; Department of Medical Education, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USABackground: Variation in the origin and course of the left vertebral artery have surgical and clinical implications in the management of medical conditions. Here, we show variant origin of the left vertebral artery in cadavers and propose potential causes for future molecular investigations. Method: The aortic arches of 32 donors were dissected and observed for anomalous origin of the left vertebral artery in the cadaver laboratory at the University of Toledo, Ohio, USA. Results: Out of 32 donors dissected during laboratory sessions, we observed two cases of the left vertebral artery originating directly from the aortic arch, medial to the left subclavian artery. Conclusion: The study aims to stimulate discussions and future investigations into the molecular embryology of vasculogenesis concomitant with preconceptional and in utero exposures to understand the underlying causes of aberrant origin of the left vertebral artery. Additionally, we speculate that parental and embryonic environmental exposures influence the epigenetic landscape in germ cells and early embryos, thereby contributing to the programming of variant origin of blood vessels.http://www.sciencedirect.com/science/article/pii/S2214854X25000408Left Vertebral Artery (LVA)Aortic archLeft Subclavian Artery (LSA)EpigeneticsAtherosclerosis |
| spellingShingle | Connor Lee McCoy John Joseph Cichewicz Rainevan Miller Soumya Sharma Adel Maklad Eistine Boateng Aberrant origin of left vertebral artery: A molecular embryological perspective Translational Research in Anatomy Left Vertebral Artery (LVA) Aortic arch Left Subclavian Artery (LSA) Epigenetics Atherosclerosis |
| title | Aberrant origin of left vertebral artery: A molecular embryological perspective |
| title_full | Aberrant origin of left vertebral artery: A molecular embryological perspective |
| title_fullStr | Aberrant origin of left vertebral artery: A molecular embryological perspective |
| title_full_unstemmed | Aberrant origin of left vertebral artery: A molecular embryological perspective |
| title_short | Aberrant origin of left vertebral artery: A molecular embryological perspective |
| title_sort | aberrant origin of left vertebral artery a molecular embryological perspective |
| topic | Left Vertebral Artery (LVA) Aortic arch Left Subclavian Artery (LSA) Epigenetics Atherosclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S2214854X25000408 |
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