Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease
Abstract There is currently no effective therapy for prion diseases. The glymphatic system is an organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain. This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesen...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | https://doi.org/10.1186/s13024-025-00835-y |
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| _version_ | 1850156517120016384 |
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| author | Mohammed Zayed Yong-Chan Kim Byung-Hoon Jeong |
| author_facet | Mohammed Zayed Yong-Chan Kim Byung-Hoon Jeong |
| author_sort | Mohammed Zayed |
| collection | DOAJ |
| description | Abstract There is currently no effective therapy for prion diseases. The glymphatic system is an organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain. This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesenchymal stem cells (AdMSCs) and a glymphatic system-activated drug, clonidine, against prion disease. The therapy has the potential to clear PrPSc accumulation, ameliorate astrocytosis, and prolong the survival time of ME7-infected mice. |
| format | Article |
| id | doaj-art-162f5eef8cd84ef398002b335bd3726e |
| institution | OA Journals |
| issn | 1750-1326 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj-art-162f5eef8cd84ef398002b335bd3726e2025-08-20T02:24:30ZengBMCMolecular Neurodegeneration1750-13262025-04-012011410.1186/s13024-025-00835-yTherapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion diseaseMohammed Zayed0Yong-Chan Kim1Byung-Hoon Jeong2Korea Zoonosis Research Institute, Jeonbuk National UniversityDepartment of Biological Sciences, Andong National UniversityKorea Zoonosis Research Institute, Jeonbuk National UniversityAbstract There is currently no effective therapy for prion diseases. The glymphatic system is an organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain. This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesenchymal stem cells (AdMSCs) and a glymphatic system-activated drug, clonidine, against prion disease. The therapy has the potential to clear PrPSc accumulation, ameliorate astrocytosis, and prolong the survival time of ME7-infected mice.https://doi.org/10.1186/s13024-025-00835-y |
| spellingShingle | Mohammed Zayed Yong-Chan Kim Byung-Hoon Jeong Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease Molecular Neurodegeneration |
| title | Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease |
| title_full | Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease |
| title_fullStr | Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease |
| title_full_unstemmed | Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease |
| title_short | Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease |
| title_sort | therapeutic effects of adipose derived mesenchymal stem cells combined with glymphatic system activation in prion disease |
| url | https://doi.org/10.1186/s13024-025-00835-y |
| work_keys_str_mv | AT mohammedzayed therapeuticeffectsofadiposederivedmesenchymalstemcellscombinedwithglymphaticsystemactivationinpriondisease AT yongchankim therapeuticeffectsofadiposederivedmesenchymalstemcellscombinedwithglymphaticsystemactivationinpriondisease AT byunghoonjeong therapeuticeffectsofadiposederivedmesenchymalstemcellscombinedwithglymphaticsystemactivationinpriondisease |