Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma
Background and purpose: The aim is to investigate whether lumbar skeletal muscle index (LSMI) decreases during treatment of head and neck squamous cell carcinoma (HNSCC) patients, and which pre-treatment variables are associated with change. Materials and methods: The LSMI before and during treatmen...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Oral Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906025000251 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849733734547324928 |
|---|---|
| author | Anouk W.M.A. Schaeffers Hannah A. Scholten Annemieke Kok Floris C.J. Reinders Rebecca K. Stellato Ernst J. Smid Maartje A. van Beers Carla H. van Gils Caroline M. Speksnijder Marielle P. Philippens Lot A. Devriese Remco de Bree |
| author_facet | Anouk W.M.A. Schaeffers Hannah A. Scholten Annemieke Kok Floris C.J. Reinders Rebecca K. Stellato Ernst J. Smid Maartje A. van Beers Carla H. van Gils Caroline M. Speksnijder Marielle P. Philippens Lot A. Devriese Remco de Bree |
| author_sort | Anouk W.M.A. Schaeffers |
| collection | DOAJ |
| description | Background and purpose: The aim is to investigate whether lumbar skeletal muscle index (LSMI) decreases during treatment of head and neck squamous cell carcinoma (HNSCC) patients, and which pre-treatment variables are associated with change. Materials and methods: The LSMI before and during treatment was assessed using MRI scans of HNSCC patients treated with radiotherapy (RT) or chemoradiotherapy (CRT). Mixed models assessed LSMI change and pre-treatment covariates (i.e. age, BMI, tumor characteristics and treatment type). Results: In 63 patients the LSMI decreased from 40.56 cm2/m2 to 39.96 cm2/m2 (p trend = 0.008) on average. The LSMI of CRT patients decreased more than the LSMI of RT patients, but this was not significant (40.85–39.63 cm2/m2 vs. 40.37 to 40.19 cm2/m2; p-interaction = 0.052). No effects of pre-treatment covariates on the LSMI trend over time were observed. Conclusion: LSMI decreased during treatment in HNSCC patients, which was not related to pre-treatment variables, but seemed slightly larger for CRT patients than RT patients. |
| format | Article |
| id | doaj-art-162da3d2f524402c922b394fb0cf119a |
| institution | DOAJ |
| issn | 2772-9060 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-162da3d2f524402c922b394fb0cf119a2025-08-20T03:07:58ZengElsevierOral Oncology Reports2772-90602025-06-011410073710.1016/j.oor.2025.100737Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinomaAnouk W.M.A. Schaeffers0Hannah A. Scholten1Annemieke Kok2Floris C.J. Reinders3Rebecca K. Stellato4Ernst J. Smid5Maartje A. van Beers6Carla H. van Gils7Caroline M. Speksnijder8Marielle P. Philippens9Lot A. Devriese10Remco de Bree11Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Dietetics, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Oral and Maxillofacial Surgery and Special Dental Care, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the NetherlandsDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Corresponding author. Huispostnummer Q05.4.300, P.O. Box 85500, Heidelberglaan 100, 3508 GA, Utrecht, the Netherlands.Background and purpose: The aim is to investigate whether lumbar skeletal muscle index (LSMI) decreases during treatment of head and neck squamous cell carcinoma (HNSCC) patients, and which pre-treatment variables are associated with change. Materials and methods: The LSMI before and during treatment was assessed using MRI scans of HNSCC patients treated with radiotherapy (RT) or chemoradiotherapy (CRT). Mixed models assessed LSMI change and pre-treatment covariates (i.e. age, BMI, tumor characteristics and treatment type). Results: In 63 patients the LSMI decreased from 40.56 cm2/m2 to 39.96 cm2/m2 (p trend = 0.008) on average. The LSMI of CRT patients decreased more than the LSMI of RT patients, but this was not significant (40.85–39.63 cm2/m2 vs. 40.37 to 40.19 cm2/m2; p-interaction = 0.052). No effects of pre-treatment covariates on the LSMI trend over time were observed. Conclusion: LSMI decreased during treatment in HNSCC patients, which was not related to pre-treatment variables, but seemed slightly larger for CRT patients than RT patients.http://www.sciencedirect.com/science/article/pii/S2772906025000251ChemoradiotherapyCisplatinSkeletal muscle massChange of muscle massHead and neck oncology |
| spellingShingle | Anouk W.M.A. Schaeffers Hannah A. Scholten Annemieke Kok Floris C.J. Reinders Rebecca K. Stellato Ernst J. Smid Maartje A. van Beers Carla H. van Gils Caroline M. Speksnijder Marielle P. Philippens Lot A. Devriese Remco de Bree Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma Oral Oncology Reports Chemoradiotherapy Cisplatin Skeletal muscle mass Change of muscle mass Head and neck oncology |
| title | Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma |
| title_full | Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma |
| title_fullStr | Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma |
| title_full_unstemmed | Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma |
| title_short | Change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma |
| title_sort | change of skeletal muscle mass and associated factors during radiotherapy and chemoradiotherapy in patients with head and neck squamous cell carcinoma |
| topic | Chemoradiotherapy Cisplatin Skeletal muscle mass Change of muscle mass Head and neck oncology |
| url | http://www.sciencedirect.com/science/article/pii/S2772906025000251 |
| work_keys_str_mv | AT anoukwmaschaeffers changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT hannahascholten changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT annemiekekok changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT floriscjreinders changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT rebeccakstellato changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT ernstjsmid changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT maartjeavanbeers changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT carlahvangils changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT carolinemspeksnijder changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT mariellepphilippens changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT lotadevriese changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma AT remcodebree changeofskeletalmusclemassandassociatedfactorsduringradiotherapyandchemoradiotherapyinpatientswithheadandnecksquamouscellcarcinoma |