Human naïve B cells show evidence of anergy and clonal redemption following vaccination

Abstract In an era of predicted emerging pandemics, the production of effective vaccines may require an in-depth understanding of the biology of human naive B (BN) cells. Here we provide evidence that the majority of BN cells expressed CD73, an ecto-5’-nucleotidase often associated with immune cell...

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Bibliographic Details
Main Authors: Brian L. P. Dizon, Prasida Holla, Evan C. Mutic, Paul Schaughency, Susan K. Pierce
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01133-w
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