Benzbromarone interferes with the interaction between Hsp90 and Aha1 by interacting with both of them

Benzbromarone interferes with the interaction between Hsp90 and Aha1 by interacting with both of them

Abstract Aha1 is one of the well-known co-chaperones of Hsp90. However, the action mode of Aha1 has not been fully elucidated yet, and the binding mode of Aha1’s C-terminal domain (Aha1-CTD) to Hsp90 is still under discussion. Meanwhile, since both Hsp90 and Aha1 contribute to tumorigenesis through...

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Main Authors: Yan Zhong, Li Shi, Zhuo Xu, Jing Gao, Qingyu Ma, Tianqi Gao, Junying Tang, Muya Xiong, Yechun Xu, Huixiong Dai, Hu Zhou, Naixia Zhang, Chen Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08189-3
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