Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study
Objective To determine the variation of serum AMH levels in healthy Chinese women and establish AMH reference ranges accordingly.Methods This prospective cross-sectional multicenter study was designed to enroll healthy Chinese women of reproductive age (20–39 years) and perimenopausal age (40–49 yea...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Gynecological Endocrinology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2024.2431230 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841525435662336000 |
|---|---|
| author | Linli Hu Hongyi Yang Haining Luo Yuexiang Zhang Xiaohong Wang Sanhua Wei Qiongfang Wu Ying Jiang Xiaoyan Liang Jianhui Chen Yingpu Sun† |
| author_facet | Linli Hu Hongyi Yang Haining Luo Yuexiang Zhang Xiaohong Wang Sanhua Wei Qiongfang Wu Ying Jiang Xiaoyan Liang Jianhui Chen Yingpu Sun† |
| author_sort | Linli Hu |
| collection | DOAJ |
| description | Objective To determine the variation of serum AMH levels in healthy Chinese women and establish AMH reference ranges accordingly.Methods This prospective cross-sectional multicenter study was designed to enroll healthy Chinese women of reproductive age (20–39 years) and perimenopausal age (40–49 years) from five reproductive centers in different regions of China. The study began in May 2022 and finished in February 2023. Age-specific 2.5th–97.5th percentiles AMH reference ranges were established. Multivariable linear regressions were undertaken to analyze the association of serum AMH with different demographic and clinical variables, including antral follicle count (AFC).Results 1113 healthy Chinese women were enrolled, including 614 of premenopausal age and others of reproductive age. The AMH (ng/ml) reference ranges for Chinese women of reproductive age were 0.87–9.89 (20–24 years), 0.42–8.24 (25–29 years), 0.34–7.46 (30–34 years), and 0.28–5.66 (35–39 years). For perimenopausal women, their reference ranges were 0.12–4.63 (40–41 years), 0.01–4.12 (42–43 years), 0.01–2.65 (44–45 years), 0.01–1.90 (46–47 years), and 0.01–1.08 (48–49 years). The regression of AMH on AFC adjusted by age is Log10(AMH)=0.2594–0.0235*Age + 0.0632*AFC.Conclusions This study established the age-specific serum AMH reference ranges for healthy Chinese women of reproductive and premenopausal age, and observed that the consistent decrease of AMH after 20 years accelerated around the beginning of perimenopause (40 years). |
| format | Article |
| id | doaj-art-16287601986f40098963004b4e08e7bc |
| institution | Kabale University |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-16287601986f40098963004b4e08e7bc2025-01-17T11:06:03ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662025-12-0141110.1080/09513590.2024.2431230Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional studyLinli Hu0Hongyi Yang1Haining Luo2Yuexiang Zhang3Xiaohong Wang4Sanhua Wei5Qiongfang Wu6Ying Jiang7Xiaoyan Liang8Jianhui Chen9Yingpu Sun†10Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCenter for Reproductive Medicine, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, ChinaCenter for Reproductive Medicine, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, ChinaDepartment of Obstetrics and Gynecology, Tangdu Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Obstetrics and Gynecology, Tangdu Hospital, Air Force Medical University, Xi’an, ChinaCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Nanchang, ChinaCenter for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Nanchang, ChinaReproductive Medicine Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaReproductive Medicine Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaObjective To determine the variation of serum AMH levels in healthy Chinese women and establish AMH reference ranges accordingly.Methods This prospective cross-sectional multicenter study was designed to enroll healthy Chinese women of reproductive age (20–39 years) and perimenopausal age (40–49 years) from five reproductive centers in different regions of China. The study began in May 2022 and finished in February 2023. Age-specific 2.5th–97.5th percentiles AMH reference ranges were established. Multivariable linear regressions were undertaken to analyze the association of serum AMH with different demographic and clinical variables, including antral follicle count (AFC).Results 1113 healthy Chinese women were enrolled, including 614 of premenopausal age and others of reproductive age. The AMH (ng/ml) reference ranges for Chinese women of reproductive age were 0.87–9.89 (20–24 years), 0.42–8.24 (25–29 years), 0.34–7.46 (30–34 years), and 0.28–5.66 (35–39 years). For perimenopausal women, their reference ranges were 0.12–4.63 (40–41 years), 0.01–4.12 (42–43 years), 0.01–2.65 (44–45 years), 0.01–1.90 (46–47 years), and 0.01–1.08 (48–49 years). The regression of AMH on AFC adjusted by age is Log10(AMH)=0.2594–0.0235*Age + 0.0632*AFC.Conclusions This study established the age-specific serum AMH reference ranges for healthy Chinese women of reproductive and premenopausal age, and observed that the consistent decrease of AMH after 20 years accelerated around the beginning of perimenopause (40 years).https://www.tandfonline.com/doi/10.1080/09513590.2024.2431230Anti-mülerian hormoneperimenopausereference rangenationwide-population based studyovarian reserve |
| spellingShingle | Linli Hu Hongyi Yang Haining Luo Yuexiang Zhang Xiaohong Wang Sanhua Wei Qiongfang Wu Ying Jiang Xiaoyan Liang Jianhui Chen Yingpu Sun† Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study Gynecological Endocrinology Anti-mülerian hormone perimenopause reference range nationwide-population based study ovarian reserve |
| title | Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study |
| title_full | Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study |
| title_fullStr | Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study |
| title_full_unstemmed | Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study |
| title_short | Age-specific reference ranges and variation of anti-mülerian hormone in healthy Chinese women of reproductive and perimenopausal age: a nationwide population-based prospective multicenter cross-sectional study |
| title_sort | age specific reference ranges and variation of anti mulerian hormone in healthy chinese women of reproductive and perimenopausal age a nationwide population based prospective multicenter cross sectional study |
| topic | Anti-mülerian hormone perimenopause reference range nationwide-population based study ovarian reserve |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2024.2431230 |
| work_keys_str_mv | AT linlihu agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT hongyiyang agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT hainingluo agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT yuexiangzhang agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT xiaohongwang agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT sanhuawei agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT qiongfangwu agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT yingjiang agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT xiaoyanliang agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT jianhuichen agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy AT yingpusun agespecificreferencerangesandvariationofantimulerianhormoneinhealthychinesewomenofreproductiveandperimenopausalageanationwidepopulationbasedprospectivemulticentercrosssectionalstudy |