The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery
Abstract To evaluate influence of total antioxidant capacity expression (TAC) on outcome of kerato-lenticule extraction (KLEx). A prospective non-randomized trial was conducted and patients received KLEx were categorized via TAC concentration. A total of 56 and 36 eyes were enrolled into the low TAC...
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Nature Portfolio
2025-03-01
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| Online Access: | https://doi.org/10.1038/s41598-025-91654-0 |
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| author | Chia-Yi Lee Hung-Chi Chen Shun-Fa Yang Yi-Jen Hsueh Jing-Yang Huang Chao-Kai Chang |
| author_facet | Chia-Yi Lee Hung-Chi Chen Shun-Fa Yang Yi-Jen Hsueh Jing-Yang Huang Chao-Kai Chang |
| author_sort | Chia-Yi Lee |
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| description | Abstract To evaluate influence of total antioxidant capacity expression (TAC) on outcome of kerato-lenticule extraction (KLEx). A prospective non-randomized trial was conducted and patients received KLEx were categorized via TAC concentration. A total of 56 and 36 eyes were enrolled into the low TAC and high TAC groups. The main outcomes are the postoperative un-corrected visual acuity (UCVA), refraction and superficial keratitis between groups. The generalized liner model was applied for statistical analysis. One month after the KLEx surgery, the UCVA was significantly higher in the high TAC group (P = 0.028), and low TAC group associated with superficial keratitis risk compared to high TAC group (P = 0.035). The trends of TAC and ascorbic acid (AA) decrements were more significant in the low TAC group (both P < 0.05). Low TAC population and old age correlated to poor UCVA (both P < 0.05) while the thick CCT correlated to better UCVA (P = 0.030). Besides, the low TAC population (P = 0.032) correlated to higher superficial keratitis rate, while old age (P = 0.018) correlated to lower superficial keratitis rate. The presence of low TAC expression correlated to worse UCVA and higher risk of superficial keratitis after KLEx. |
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| id | doaj-art-1625c4be5ffe4b6f919101312ebbcf2c |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-1625c4be5ffe4b6f919101312ebbcf2c2025-08-20T01:57:25ZengNature PortfolioScientific Reports2045-23222025-03-011511910.1038/s41598-025-91654-0The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgeryChia-Yi Lee0Hung-Chi Chen1Shun-Fa Yang2Yi-Jen Hsueh3Jing-Yang Huang4Chao-Kai Chang5Institute of Medicine, Chung Shan Medical UniversityDepartment of Ophthalmology, Chang Gung Memorial HospitalInstitute of Medicine, Chung Shan Medical UniversityDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Medical Research, Chung Shan Medical University HospitalNobel Eye InstituteAbstract To evaluate influence of total antioxidant capacity expression (TAC) on outcome of kerato-lenticule extraction (KLEx). A prospective non-randomized trial was conducted and patients received KLEx were categorized via TAC concentration. A total of 56 and 36 eyes were enrolled into the low TAC and high TAC groups. The main outcomes are the postoperative un-corrected visual acuity (UCVA), refraction and superficial keratitis between groups. The generalized liner model was applied for statistical analysis. One month after the KLEx surgery, the UCVA was significantly higher in the high TAC group (P = 0.028), and low TAC group associated with superficial keratitis risk compared to high TAC group (P = 0.035). The trends of TAC and ascorbic acid (AA) decrements were more significant in the low TAC group (both P < 0.05). Low TAC population and old age correlated to poor UCVA (both P < 0.05) while the thick CCT correlated to better UCVA (P = 0.030). Besides, the low TAC population (P = 0.032) correlated to higher superficial keratitis rate, while old age (P = 0.018) correlated to lower superficial keratitis rate. The presence of low TAC expression correlated to worse UCVA and higher risk of superficial keratitis after KLEx.https://doi.org/10.1038/s41598-025-91654-0Kerato-lenticule extractionUn-corrected visual acuitySuperficial keratitisAscorbic acidTotal antioxidant capacity |
| spellingShingle | Chia-Yi Lee Hung-Chi Chen Shun-Fa Yang Yi-Jen Hsueh Jing-Yang Huang Chao-Kai Chang The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery Scientific Reports Kerato-lenticule extraction Un-corrected visual acuity Superficial keratitis Ascorbic acid Total antioxidant capacity |
| title | The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery |
| title_full | The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery |
| title_fullStr | The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery |
| title_full_unstemmed | The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery |
| title_short | The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery |
| title_sort | effect of preoperative total antioxidant capacity on short term outcomes after kerato lenticule extraction surgery |
| topic | Kerato-lenticule extraction Un-corrected visual acuity Superficial keratitis Ascorbic acid Total antioxidant capacity |
| url | https://doi.org/10.1038/s41598-025-91654-0 |
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