Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey
ObjectivesCognitive impairment is a major health concern in older adults with hypertension, and both depression and abnormal sleep duration are recognized as potential contributing factors. This study aimed to explore the nonlinear association of depression and sleep duration with cognitive impairme...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1579560/full |
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| author | Hui-Ying Fan Hui-Ying Fan Hui-Ying Fan He-Li Sun He-Li Sun Yuan Feng Qinge Zhang Hua-Qing Xing Hua-Qing Xing Qian-Hua Huang Qian-Hua Huang Zhaohui Su Teris Cheung Chee H. Ng Yu-Tao Xiang Yu-Tao Xiang Gang Wang |
| author_facet | Hui-Ying Fan Hui-Ying Fan Hui-Ying Fan He-Li Sun He-Li Sun Yuan Feng Qinge Zhang Hua-Qing Xing Hua-Qing Xing Qian-Hua Huang Qian-Hua Huang Zhaohui Su Teris Cheung Chee H. Ng Yu-Tao Xiang Yu-Tao Xiang Gang Wang |
| author_sort | Hui-Ying Fan |
| collection | DOAJ |
| description | ObjectivesCognitive impairment is a major health concern in older adults with hypertension, and both depression and abnormal sleep duration are recognized as potential contributing factors. This study aimed to explore the nonlinear association of depression and sleep duration with cognitive impairment among older adults with hypertension.MethodsThis cross-sectional study was based on the 2017–2018 wave of Chinese Longitudinal Healthy Longevity Survey. Depression and cognitive function were measured using the 10-item Center for Epidemiological Studies Short Depression Scale and Mini Mental State Examination, respectively. Univariate, binary logistic regression, and restricted cubic spline regression analyses were used to examine the associations between depression, sleep duration and cognitive impairment.ResultsA total of 3,989 older adults with hypertension were included. The prevalence of depression and cognitive impairment were 28.1% (95%CI = 26.7–29.5%) and 10.1% (95%CI = 9.2–11.1%), respectively. After adjusting for confounding factors, a significant linear association (nonlinear p = 0.814) between depression and cognitive impairment risk was found, while a U-shaped nonlinear association was identified between sleep duration and cognitive impairment risk (p = 0.040). Both shorter (<6.6 h) and longer (>7.7 h) sleep duration per day were associated with higher cognitive impairment risk, with an inflection point at 7.3 h. The effect of sleep duration on cognitive impairment risk was more significant for participants with a higher (≥ 6 years) education level.ConclusionThis study highlights the importance of managing depression and optimizing sleep duration in addressing the risk of cognitive decline in older adults with hypertension. |
| format | Article |
| id | doaj-art-161833db71c7449193fb5cd928f13c9c |
| institution | DOAJ |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-161833db71c7449193fb5cd928f13c9c2025-08-20T02:39:25ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-07-011710.3389/fnagi.2025.15795601579560Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national surveyHui-Ying Fan0Hui-Ying Fan1Hui-Ying Fan2He-Li Sun3He-Li Sun4Yuan Feng5Qinge Zhang6Hua-Qing Xing7Hua-Qing Xing8Qian-Hua Huang9Qian-Hua Huang10Zhaohui Su11Teris Cheung12Chee H. Ng13Yu-Tao Xiang14Yu-Tao Xiang15Gang Wang16International Nursing School, Hainan Medical University, Haikou, Hainan, ChinaUnit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao SAR, ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macao SAR, ChinaUnit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao SAR, ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macao SAR, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaUnit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao SAR, ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macao SAR, ChinaUnit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao SAR, ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macao SAR, ChinaSchool of Public Health, Southeast University, Nanjing, ChinaSchool of Nursing, Hong Kong Polytechnic University, Hong Kong SAR, ChinaDepartment of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, VIC, AustraliaUnit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao SAR, ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macao SAR, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaObjectivesCognitive impairment is a major health concern in older adults with hypertension, and both depression and abnormal sleep duration are recognized as potential contributing factors. This study aimed to explore the nonlinear association of depression and sleep duration with cognitive impairment among older adults with hypertension.MethodsThis cross-sectional study was based on the 2017–2018 wave of Chinese Longitudinal Healthy Longevity Survey. Depression and cognitive function were measured using the 10-item Center for Epidemiological Studies Short Depression Scale and Mini Mental State Examination, respectively. Univariate, binary logistic regression, and restricted cubic spline regression analyses were used to examine the associations between depression, sleep duration and cognitive impairment.ResultsA total of 3,989 older adults with hypertension were included. The prevalence of depression and cognitive impairment were 28.1% (95%CI = 26.7–29.5%) and 10.1% (95%CI = 9.2–11.1%), respectively. After adjusting for confounding factors, a significant linear association (nonlinear p = 0.814) between depression and cognitive impairment risk was found, while a U-shaped nonlinear association was identified between sleep duration and cognitive impairment risk (p = 0.040). Both shorter (<6.6 h) and longer (>7.7 h) sleep duration per day were associated with higher cognitive impairment risk, with an inflection point at 7.3 h. The effect of sleep duration on cognitive impairment risk was more significant for participants with a higher (≥ 6 years) education level.ConclusionThis study highlights the importance of managing depression and optimizing sleep duration in addressing the risk of cognitive decline in older adults with hypertension.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1579560/fullolder adultshypertensioncognitive impairmentdepressionsleep duration |
| spellingShingle | Hui-Ying Fan Hui-Ying Fan Hui-Ying Fan He-Li Sun He-Li Sun Yuan Feng Qinge Zhang Hua-Qing Xing Hua-Qing Xing Qian-Hua Huang Qian-Hua Huang Zhaohui Su Teris Cheung Chee H. Ng Yu-Tao Xiang Yu-Tao Xiang Gang Wang Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey Frontiers in Aging Neuroscience older adults hypertension cognitive impairment depression sleep duration |
| title | Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey |
| title_full | Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey |
| title_fullStr | Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey |
| title_full_unstemmed | Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey |
| title_short | Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey |
| title_sort | nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension findings from a national survey |
| topic | older adults hypertension cognitive impairment depression sleep duration |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1579560/full |
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