High-LET Proton Irradiation Significantly Alters the Clonogenic and Tumorigenic Potential of Human Breast Cancer Cell Lines In Vitro and In Vivo

High-LET Proton Irradiation Significantly Alters the Clonogenic and Tumorigenic Potential of Human Breast Cancer Cell Lines In Vitro and In Vivo

Background: The implementation of proton beam irradiation (PBI) for breast cancer (BC) treatment is rapidly advancing due to its enhanced target coverage and reduced toxicities to organs at risk. However, the effects of PBI can vary depending on the cell type. This study aimed to...

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Bibliographic Details
Main Authors: Margarita Pustovalova, Rita Mohammad, Yuzhe Wang, Wenyu Xue, Philipp Malakhov, Viktor Nekrasov, Elizaveta Kontareva, Zain Nofal, Vyacheslav Saburov, Dmitry Kolesov, Andreyan Osipov, Sergey Leonov
Format: Article
Language:English
Published: IMR Press 2025-04-01
Series:Frontiers in Bioscience-Landmark
Subjects:
breast cancer
proton therapy
dna damage repair
extracellular matrix (ecm) stiffness
stress-induced premature senescence (sips)
entosis
stiffness of tumor cell membranes
mechanosensation
chick embryo chorioallantoic membrane (cam) model
Online Access:https://www.imrpress.com/journal/FBL/30/4/10.31083/FBL36415
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