Investigation of epilepsy-related genes in a Drosophila model
Complex genetic architecture is the major cause of heterogeneity in epilepsy, which poses challenges for accurate diagnosis and precise treatment. A large number of epilepsy candidate genes have been identified from clinical studies, particularly with the widespread use of next-generation sequencing...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2026-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/NRR.NRR-D-24-00877 |
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| author | Xiaochong Qu Xiaodan Lai Mingfeng He Jinyuan Zhang Binbin Xiang Chuqiao Liu Ruina Huang Yiwu Shi Jingda Qiao |
| author_facet | Xiaochong Qu Xiaodan Lai Mingfeng He Jinyuan Zhang Binbin Xiang Chuqiao Liu Ruina Huang Yiwu Shi Jingda Qiao |
| author_sort | Xiaochong Qu |
| collection | DOAJ |
| description | Complex genetic architecture is the major cause of heterogeneity in epilepsy, which poses challenges for accurate diagnosis and precise treatment. A large number of epilepsy candidate genes have been identified from clinical studies, particularly with the widespread use of next-generation sequencing. Validating these candidate genes is emerging as a valuable yet challenging task. Drosophila serves as an ideal animal model for validating candidate genes associated with neurogenetic disorders such as epilepsy, due to its rapid reproduction rate, powerful genetic tools, and efficient use of ethological and electrophysiological assays. Here, we systematically summarize the advantageous techniques of the Drosophila model used to investigate epilepsy genes, including genetic tools for manipulating target gene expression, ethological assays for seizure-like behaviors, electrophysiological techniques, and functional imaging for recording neural activity. We then introduce several typical strategies for identifying epilepsy genes and provide new insights into gene‒gene interactions in epilepsy with polygenic causes. We summarize well-established precision medicine strategies for epilepsy and discuss prospective treatment options, including drug therapy and gene therapy for genetic epilepsy based on the Drosophila model. Finally, we also address genetic counseling and assisted reproductive technology as potential approaches for the prevention of genetic epilepsy. |
| format | Article |
| id | doaj-art-160b4bfa8e1c4d128d21576916a246a2 |
| institution | OA Journals |
| issn | 1673-5374 1876-7958 |
| language | English |
| publishDate | 2026-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj-art-160b4bfa8e1c4d128d21576916a246a22025-08-20T01:53:19ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582026-01-0121119521110.4103/NRR.NRR-D-24-00877Investigation of epilepsy-related genes in a Drosophila modelXiaochong QuXiaodan LaiMingfeng HeJinyuan ZhangBinbin XiangChuqiao LiuRuina HuangYiwu ShiJingda QiaoComplex genetic architecture is the major cause of heterogeneity in epilepsy, which poses challenges for accurate diagnosis and precise treatment. A large number of epilepsy candidate genes have been identified from clinical studies, particularly with the widespread use of next-generation sequencing. Validating these candidate genes is emerging as a valuable yet challenging task. Drosophila serves as an ideal animal model for validating candidate genes associated with neurogenetic disorders such as epilepsy, due to its rapid reproduction rate, powerful genetic tools, and efficient use of ethological and electrophysiological assays. Here, we systematically summarize the advantageous techniques of the Drosophila model used to investigate epilepsy genes, including genetic tools for manipulating target gene expression, ethological assays for seizure-like behaviors, electrophysiological techniques, and functional imaging for recording neural activity. We then introduce several typical strategies for identifying epilepsy genes and provide new insights into gene‒gene interactions in epilepsy with polygenic causes. We summarize well-established precision medicine strategies for epilepsy and discuss prospective treatment options, including drug therapy and gene therapy for genetic epilepsy based on the Drosophila model. Finally, we also address genetic counseling and assisted reproductive technology as potential approaches for the prevention of genetic epilepsy.https://journals.lww.com/10.4103/NRR.NRR-D-24-00877drosophila melanogasterelectrophysiologyepilepsygeneticsmorphologyneurogenetic diseasespolygeneprecision medicineseizure behavioruas/gal4 system |
| spellingShingle | Xiaochong Qu Xiaodan Lai Mingfeng He Jinyuan Zhang Binbin Xiang Chuqiao Liu Ruina Huang Yiwu Shi Jingda Qiao Investigation of epilepsy-related genes in a Drosophila model Neural Regeneration Research drosophila melanogaster electrophysiology epilepsy genetics morphology neurogenetic diseases polygene precision medicine seizure behavior uas/gal4 system |
| title | Investigation of epilepsy-related genes in a Drosophila model |
| title_full | Investigation of epilepsy-related genes in a Drosophila model |
| title_fullStr | Investigation of epilepsy-related genes in a Drosophila model |
| title_full_unstemmed | Investigation of epilepsy-related genes in a Drosophila model |
| title_short | Investigation of epilepsy-related genes in a Drosophila model |
| title_sort | investigation of epilepsy related genes in a drosophila model |
| topic | drosophila melanogaster electrophysiology epilepsy genetics morphology neurogenetic diseases polygene precision medicine seizure behavior uas/gal4 system |
| url | https://journals.lww.com/10.4103/NRR.NRR-D-24-00877 |
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