Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia
Background: To investigate the hematological features of infants with bronchopulmonary dysplasia (BPD) and their relationships with clinical severity. Methods: This prospective observational study enrolled 73 BPD patients from a total of 331 infants with a birth weight of <1500 g from 2005 to 201...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957218301001 |
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| author | Hiroaki Kurata Masayuki Ochiai Hirosuke Inoue Takeshi Kusuda Junko Fujiyoshi Masako Ichiyama Yoshifumi Wakata Hidetoshi Takada |
| author_facet | Hiroaki Kurata Masayuki Ochiai Hirosuke Inoue Takeshi Kusuda Junko Fujiyoshi Masako Ichiyama Yoshifumi Wakata Hidetoshi Takada |
| author_sort | Hiroaki Kurata |
| collection | DOAJ |
| description | Background: To investigate the hematological features of infants with bronchopulmonary dysplasia (BPD) and their relationships with clinical severity. Methods: This prospective observational study enrolled 73 BPD patients from a total of 331 infants with a birth weight of <1500 g from 2005 to 2013. The clinical severity of BPD was defined by the duration of oxygen supplementation and positive pressure ventilation (PPV) in line with the diagnostic criteria of BPD. The hematological status and cytokine levels were surveyed from blood samples at birth and at 2 and 4 weeks of life. Results: Thirty-four (46.6%) cases were classified as “moderate-to-severe” BPD. Small-for-gestational-age (SGA) was associated with the severity of BPD (OR: 5.05; 95% CI: 1.45 to 17.2). The CRP level at 2 weeks (partial regression coefficient [rc]: 21.8; 4.01 to 39.7) and the neutrophil count at 4 weeks (0.005; 0.001 to 0.007) were positively correlated with the oxygenation period. The PPV period was found to be correlated with the CRP level at 2 weeks (27.2; 14.9 to 39.5), and the neutrophil count (0.003; 0.001 to 0.004) at 4 weeks. Conclusion: The aggravation of BPD was associated with both SGA at birth and inflammation during neonatal period. Key Words: chronic lung disease, etiology, factor, small-for-gestational-age |
| format | Article |
| id | doaj-art-160a52a1df4348ff99d730e88820565a |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-160a52a1df4348ff99d730e88820565a2025-08-20T02:02:43ZengElsevierPediatrics and Neonatology1875-95722019-10-0160549650310.1016/j.pedneo.2018.11.007Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasiaHiroaki Kurata0Masayuki Ochiai1Hirosuke Inoue2Takeshi Kusuda3Junko Fujiyoshi4Masako Ichiyama5Yoshifumi Wakata6Hidetoshi Takada7Comprehensive Maternity and Perinatal Care Center, Kyushu University Hospital, Fukuoka, Japan; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Corresponding author.Comprehensive Maternity and Perinatal Care Center, Kyushu University Hospital, Fukuoka, Japan; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Corresponding author. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Fax: +81 92 642 5435.Comprehensive Maternity and Perinatal Care Center, Kyushu University Hospital, Fukuoka, Japan; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Pediatrics, Yamaguchi University, Ube, JapanComprehensive Maternity and Perinatal Care Center, Kyushu University Hospital, Fukuoka, Japan; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanComprehensive Maternity and Perinatal Care Center, Kyushu University Hospital, Fukuoka, Japan; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanMedical Information Center, Kyushu University Hospital, Fukuoka, JapanDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Perinatal and Pediatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanBackground: To investigate the hematological features of infants with bronchopulmonary dysplasia (BPD) and their relationships with clinical severity. Methods: This prospective observational study enrolled 73 BPD patients from a total of 331 infants with a birth weight of <1500 g from 2005 to 2013. The clinical severity of BPD was defined by the duration of oxygen supplementation and positive pressure ventilation (PPV) in line with the diagnostic criteria of BPD. The hematological status and cytokine levels were surveyed from blood samples at birth and at 2 and 4 weeks of life. Results: Thirty-four (46.6%) cases were classified as “moderate-to-severe” BPD. Small-for-gestational-age (SGA) was associated with the severity of BPD (OR: 5.05; 95% CI: 1.45 to 17.2). The CRP level at 2 weeks (partial regression coefficient [rc]: 21.8; 4.01 to 39.7) and the neutrophil count at 4 weeks (0.005; 0.001 to 0.007) were positively correlated with the oxygenation period. The PPV period was found to be correlated with the CRP level at 2 weeks (27.2; 14.9 to 39.5), and the neutrophil count (0.003; 0.001 to 0.004) at 4 weeks. Conclusion: The aggravation of BPD was associated with both SGA at birth and inflammation during neonatal period. Key Words: chronic lung disease, etiology, factor, small-for-gestational-agehttp://www.sciencedirect.com/science/article/pii/S1875957218301001 |
| spellingShingle | Hiroaki Kurata Masayuki Ochiai Hirosuke Inoue Takeshi Kusuda Junko Fujiyoshi Masako Ichiyama Yoshifumi Wakata Hidetoshi Takada Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia Pediatrics and Neonatology |
| title | Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia |
| title_full | Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia |
| title_fullStr | Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia |
| title_full_unstemmed | Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia |
| title_short | Inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia |
| title_sort | inflammation in the neonatal period and intrauterine growth restriction aggravate bronchopulmonary dysplasia |
| url | http://www.sciencedirect.com/science/article/pii/S1875957218301001 |
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