CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer

CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer

BackgroundGamabufotalin (CS-6), a bufadienolide derived from Chansu, has been reported to exhibit anti-tumor effects in various cancers, including glioblastoma, nonsmall cell lung cancer, and breast cancer. However,its role in colorectal cancer (CRC) remains unexplored.ObjectiveOur study aimed to ev...

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Bibliographic Details
Main Authors: Yitong Gong, Menghan Dong, Xiaofei Feng, Naiyu Zhang, Xuehui Cui, Liushuyue Wang, Qi Qi, Chiu-fai Kuok, Qingling Jiang, Sixue Bi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
gamabufotalin (CS-6)
colorectal cancer (CRC)
DNA damage
p62
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1568339/full
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