A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis

A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis

Abstract Enterovirus D68 (EV-D68) is a respiratory virus that often causes mild to moderate respiratory illnesses and, in severe cases, can lead to paralysis and rarely death, mainly in children. There is currently no vaccine or antiviral for EV-D68. Here, we report the rational design of viral 2 C...

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Main Authors: Kan Li, Michael J. Rudy, Yanmei Hu, Haozhou Tan, George Lambrinidis, Xiangmeng Wu, Kyriakos Georgiou, Bin Tan, Joshua Frost, Courtney Wilson, Penny Clarke, Antonios Kolocouris, Qing-yu Zhang, Kenneth L. Tyler, Jun Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61083-8
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