Glucose metabolism and endometrium decidualization
Prior to embryo implantation, the endometrial stromal cells (ESCs) during the menstrual cycle undergo a significant structural and functional transformation known as decidualization to support conception. During this process, glucose consumption and utilization by endometrial cells increase to meet...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1546335/full |
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| author | Yunfei Huang Yunfei Huang Qinling Zhu Qinling Zhu Yun Sun Yun Sun |
| author_facet | Yunfei Huang Yunfei Huang Qinling Zhu Qinling Zhu Yun Sun Yun Sun |
| author_sort | Yunfei Huang |
| collection | DOAJ |
| description | Prior to embryo implantation, the endometrial stromal cells (ESCs) during the menstrual cycle undergo a significant structural and functional transformation known as decidualization to support conception. During this process, glucose consumption and utilization by endometrial cells increase to meet energy demands. Abnormal glucose metabolism in the endometrium impairs decidualization, leading to pregnancy complications, including implantation failure and pregnancy loss. However, the mechanisms modulating glucose metabolism in endometrial stromal cells during decidualization are still unclear. In this review, we describe the functions and regulation of glucose transporters (GLUTs) involved in glucose uptake, as well as the modulation of key enzymes catalyzing glucose utilization. Moreover, we present recent findings on the role of glucose related metabolites in the decidualization of ESCs. |
| format | Article |
| id | doaj-art-15ff5919da1a42b1a146bea35a72d113 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-15ff5919da1a42b1a146bea35a72d1132025-08-20T03:01:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15463351546335Glucose metabolism and endometrium decidualizationYunfei Huang0Yunfei Huang1Qinling Zhu2Qinling Zhu3Yun Sun4Yun Sun5Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, ChinaDepartment of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, ChinaShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, ChinaCenter for Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaPrior to embryo implantation, the endometrial stromal cells (ESCs) during the menstrual cycle undergo a significant structural and functional transformation known as decidualization to support conception. During this process, glucose consumption and utilization by endometrial cells increase to meet energy demands. Abnormal glucose metabolism in the endometrium impairs decidualization, leading to pregnancy complications, including implantation failure and pregnancy loss. However, the mechanisms modulating glucose metabolism in endometrial stromal cells during decidualization are still unclear. In this review, we describe the functions and regulation of glucose transporters (GLUTs) involved in glucose uptake, as well as the modulation of key enzymes catalyzing glucose utilization. Moreover, we present recent findings on the role of glucose related metabolites in the decidualization of ESCs.https://www.frontiersin.org/articles/10.3389/fendo.2025.1546335/fulldecidualizationglucose metabolismGLUTsglycolysisWarburg effect |
| spellingShingle | Yunfei Huang Yunfei Huang Qinling Zhu Qinling Zhu Yun Sun Yun Sun Glucose metabolism and endometrium decidualization Frontiers in Endocrinology decidualization glucose metabolism GLUTs glycolysis Warburg effect |
| title | Glucose metabolism and endometrium decidualization |
| title_full | Glucose metabolism and endometrium decidualization |
| title_fullStr | Glucose metabolism and endometrium decidualization |
| title_full_unstemmed | Glucose metabolism and endometrium decidualization |
| title_short | Glucose metabolism and endometrium decidualization |
| title_sort | glucose metabolism and endometrium decidualization |
| topic | decidualization glucose metabolism GLUTs glycolysis Warburg effect |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1546335/full |
| work_keys_str_mv | AT yunfeihuang glucosemetabolismandendometriumdecidualization AT yunfeihuang glucosemetabolismandendometriumdecidualization AT qinlingzhu glucosemetabolismandendometriumdecidualization AT qinlingzhu glucosemetabolismandendometriumdecidualization AT yunsun glucosemetabolismandendometriumdecidualization AT yunsun glucosemetabolismandendometriumdecidualization |