Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma.

Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma.

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Diffuse large B cell lymphomas and follicular lymphomas show recurrent mutations in epigenetic regulators; among these are loss-of-function mutations in KMT2D and gain-of-function mutations in EZH2. To systematically explore the effects of these mutations on the wiring of the epigenetic network, we...

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Bibliographic Details
Main Authors: Ofir Griess, Noa Furth, Nofar Harpaz, Nicoletta Di Bernardo, Tomer-Meir Salame, Bareket Dassa, Ioannis Karagiannidis, Yusuke Isshiki, Menachem Gross, Ari M Melnick, Wendy Béguelin, Guy Ron, Efrat Shema
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003191
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