Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.

<h4>Aims/hypothesis</h4>Sirtuin 1 (Sirt1) has been reported to be a critical positive regulator of glucose-stimulated insulin secretion in pancreatic beta-cells. The effects on islet cells and blood glucose levels when Sirt1 is deleted specifically in the pancreas are still unclear.<h...

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Main Authors: Andreia V Pinho, Mohammed Bensellam, Elke Wauters, Maxine Rees, Marc Giry-Laterriere, Amanda Mawson, Le Quan Ly, Andrew V Biankin, Jianmin Wu, D Ross Laybutt, Ilse Rooman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0128012
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