The effect of aspirin on lumbar degeneration: an imaging-based study
PurposeThis study aims to investigate how aspirin influences lumbar degeneration by analyzing the effect of aspirin on patients with low back pain (LBP) and concurrent atherosclerosis.MethodsUsing 1:1 nearest neighbor matching based on propensity score matching (PSM), 73 patients who regularly took...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2024.1515585/full |
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| author | Haiyun Niu Haiyun Niu Feiyu Zu Zhenguo Shang Ze Gao Dazhuang Miao Di Zhang |
| author_facet | Haiyun Niu Haiyun Niu Feiyu Zu Zhenguo Shang Ze Gao Dazhuang Miao Di Zhang |
| author_sort | Haiyun Niu |
| collection | DOAJ |
| description | PurposeThis study aims to investigate how aspirin influences lumbar degeneration by analyzing the effect of aspirin on patients with low back pain (LBP) and concurrent atherosclerosis.MethodsUsing 1:1 nearest neighbor matching based on propensity score matching (PSM), 73 patients who regularly took aspirin were assigned to the aspirin group, while another 73 patients who did not take aspirin formed the control group. Radiographs were used to measure lumbar lordosis (LL) and intervertebral height index (IHI). Subcutaneous fat tissue thickness (SFTT), paravertebral muscle fat infiltration area (%FIA), cartilage endplate (CEP) Modic changes, and modified Pfirrmann grading scores were performed based on lumbar MRI.ResultsAfter PSM analysis, confounders between the aspirin and control groups were balanced. A total of 73 pairs of patients were analyzed in this study. The aspirin group showed lower SFTT(L1/2) and a reduced incidence of CEP Modic changes, compared to the control group (both P < 0.05). Additionally, the %FIA and Pfirrmann scores were lower in the aspirin group, particularly in the upper lumbar spine (both P < 0.05). No significant differences were observed in LL and IHI between the aspirin and control groups.ConclusionIn summary, conservative treatment with aspirin protects against upper lumbar spine degeneration, although its effect on the lower lumbar spine is less pronounced. |
| format | Article |
| id | doaj-art-15f3bbcff3b948ff94654dc98e6fa119 |
| institution | OA Journals |
| issn | 2296-875X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Surgery |
| spelling | doaj-art-15f3bbcff3b948ff94654dc98e6fa1192025-08-20T01:58:08ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2024-12-011110.3389/fsurg.2024.15155851515585The effect of aspirin on lumbar degeneration: an imaging-based studyHaiyun Niu0Haiyun Niu1Feiyu Zu2Zhenguo Shang3Ze Gao4Dazhuang Miao5Di Zhang6Department of Spine Surgery, Hebei Medical University Third Hospital, Shijiazhuang City, Hebei, ChinaDepartment of Joint Surgery, Hebei Medical University Third Hospital, Shijiazhuang City, Hebei, ChinaDepartment of Spine Surgery, Hebei Medical University Third Hospital, Shijiazhuang City, Hebei, ChinaDepartment of Spine Surgery, Hebei Medical University Third Hospital, Shijiazhuang City, Hebei, ChinaDepartment of Spine Surgery, Hebei Medical University Third Hospital, Shijiazhuang City, Hebei, ChinaDepartment of Spine Surgery, Hebei Medical University Third Hospital, Shijiazhuang City, Hebei, ChinaDepartment of Spine Surgery, Hebei Medical University Third Hospital, Shijiazhuang City, Hebei, ChinaPurposeThis study aims to investigate how aspirin influences lumbar degeneration by analyzing the effect of aspirin on patients with low back pain (LBP) and concurrent atherosclerosis.MethodsUsing 1:1 nearest neighbor matching based on propensity score matching (PSM), 73 patients who regularly took aspirin were assigned to the aspirin group, while another 73 patients who did not take aspirin formed the control group. Radiographs were used to measure lumbar lordosis (LL) and intervertebral height index (IHI). Subcutaneous fat tissue thickness (SFTT), paravertebral muscle fat infiltration area (%FIA), cartilage endplate (CEP) Modic changes, and modified Pfirrmann grading scores were performed based on lumbar MRI.ResultsAfter PSM analysis, confounders between the aspirin and control groups were balanced. A total of 73 pairs of patients were analyzed in this study. The aspirin group showed lower SFTT(L1/2) and a reduced incidence of CEP Modic changes, compared to the control group (both P < 0.05). Additionally, the %FIA and Pfirrmann scores were lower in the aspirin group, particularly in the upper lumbar spine (both P < 0.05). No significant differences were observed in LL and IHI between the aspirin and control groups.ConclusionIn summary, conservative treatment with aspirin protects against upper lumbar spine degeneration, although its effect on the lower lumbar spine is less pronounced.https://www.frontiersin.org/articles/10.3389/fsurg.2024.1515585/fullaspirinlumbar degenerationspineMRIlow back pain |
| spellingShingle | Haiyun Niu Haiyun Niu Feiyu Zu Zhenguo Shang Ze Gao Dazhuang Miao Di Zhang The effect of aspirin on lumbar degeneration: an imaging-based study Frontiers in Surgery aspirin lumbar degeneration spine MRI low back pain |
| title | The effect of aspirin on lumbar degeneration: an imaging-based study |
| title_full | The effect of aspirin on lumbar degeneration: an imaging-based study |
| title_fullStr | The effect of aspirin on lumbar degeneration: an imaging-based study |
| title_full_unstemmed | The effect of aspirin on lumbar degeneration: an imaging-based study |
| title_short | The effect of aspirin on lumbar degeneration: an imaging-based study |
| title_sort | effect of aspirin on lumbar degeneration an imaging based study |
| topic | aspirin lumbar degeneration spine MRI low back pain |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2024.1515585/full |
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