Sensitivity of Dendritic Cells to Microenvironment Signals
Dendritic cells are antigen-presenting cells capable of either activating the immune response or inducing and maintaining immune tolerance. They do this by integrating stimuli from the environment and changing their functional status as a result of plasticity. The modifications suffered by these cel...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4753607 |
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| _version_ | 1849308542288265216 |
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| author | Juliana Maria Motta Vivian Mary Rumjanek |
| author_facet | Juliana Maria Motta Vivian Mary Rumjanek |
| author_sort | Juliana Maria Motta |
| collection | DOAJ |
| description | Dendritic cells are antigen-presenting cells capable of either activating the immune response or inducing and maintaining immune tolerance. They do this by integrating stimuli from the environment and changing their functional status as a result of plasticity. The modifications suffered by these cells have consequences in the way the organism may respond. In the present work two opposing situations known to affect dendritic cells are analyzed: tumor growth, leading to a microenvironment that favors the induction of a tolerogenic profile, and organ transplantation, which leads to a proinflammatory profile. Lessons learned from these situations may help to understand the mechanisms of modulation resulting not only from the above circumstances, but also from other pathologies. |
| format | Article |
| id | doaj-art-15eacee4cfef4abd8433020c661c3d2e |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-15eacee4cfef4abd8433020c661c3d2e2025-08-20T03:54:25ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/47536074753607Sensitivity of Dendritic Cells to Microenvironment SignalsJuliana Maria Motta0Vivian Mary Rumjanek1Laboratório de Imunologia Tumoral, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, BrazilLaboratório de Imunologia Tumoral, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, BrazilDendritic cells are antigen-presenting cells capable of either activating the immune response or inducing and maintaining immune tolerance. They do this by integrating stimuli from the environment and changing their functional status as a result of plasticity. The modifications suffered by these cells have consequences in the way the organism may respond. In the present work two opposing situations known to affect dendritic cells are analyzed: tumor growth, leading to a microenvironment that favors the induction of a tolerogenic profile, and organ transplantation, which leads to a proinflammatory profile. Lessons learned from these situations may help to understand the mechanisms of modulation resulting not only from the above circumstances, but also from other pathologies.http://dx.doi.org/10.1155/2016/4753607 |
| spellingShingle | Juliana Maria Motta Vivian Mary Rumjanek Sensitivity of Dendritic Cells to Microenvironment Signals Journal of Immunology Research |
| title | Sensitivity of Dendritic Cells to Microenvironment Signals |
| title_full | Sensitivity of Dendritic Cells to Microenvironment Signals |
| title_fullStr | Sensitivity of Dendritic Cells to Microenvironment Signals |
| title_full_unstemmed | Sensitivity of Dendritic Cells to Microenvironment Signals |
| title_short | Sensitivity of Dendritic Cells to Microenvironment Signals |
| title_sort | sensitivity of dendritic cells to microenvironment signals |
| url | http://dx.doi.org/10.1155/2016/4753607 |
| work_keys_str_mv | AT julianamariamotta sensitivityofdendriticcellstomicroenvironmentsignals AT vivianmaryrumjanek sensitivityofdendriticcellstomicroenvironmentsignals |