The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance
Colorectal cancer is the third common cancer after lung and genital cancers worldwide with more than 1.2 million new cases diagnosed annually. Although extensive progress has been made in the treatment of colorectal cancer, finding novel targets for early diagnosis and effective treatment of these p...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-05-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317705510 |
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| _version_ | 1849417711285698560 |
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| author | Mohammad Reza Sadeghi Farhad Jeddi Narges Soozangar Mohammad Hossein Somi Nasser Samadi |
| author_facet | Mohammad Reza Sadeghi Farhad Jeddi Narges Soozangar Mohammad Hossein Somi Nasser Samadi |
| author_sort | Mohammad Reza Sadeghi |
| collection | DOAJ |
| description | Colorectal cancer is the third common cancer after lung and genital cancers worldwide with more than 1.2 million new cases diagnosed annually. Although extensive progress has been made in the treatment of colorectal cancer, finding novel targets for early diagnosis and effective treatment of these patients is an urgent need. Nuclear factor-erythroid 2–kelch-like ECH-associated protein 1 signaling pathway plays a key role in protecting cells from the damage of intracellular oxidative stress and extracellular oxidizing agents. Nuclear factor-erythroid 2 is a transcription factor that creates intracellular redox homeostasis via transcriptional activity and interaction with kelch-like ECH-associated protein 1. Furthermore, it contributes to survival and chemoresistance of colorectal cancer cells which is mediated by overexpression of cytoprotective and multidrug resistance genes. In this review, the dual role of nuclear factor-erythroid 2 signaling in induction of colorectal cancer cell survival and death as well as the possibility of targeting nuclear factor-erythroid 2–kelch-like ECH-associated protein 1 axis as an advanced strategy in prevention and effective treatment of colorectal cancer patients have been discussed. |
| format | Article |
| id | doaj-art-15ea6119f5d343f3a33bce41392fa9a6 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-15ea6119f5d343f3a33bce41392fa9a62025-08-20T03:32:41ZengSAGE PublishingTumor Biology1423-03802017-05-013910.1177/1010428317705510The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistanceMohammad Reza Sadeghi0Farhad Jeddi1Narges Soozangar2Mohammad Hossein Somi3Nasser Samadi4Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranLiver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranColorectal cancer is the third common cancer after lung and genital cancers worldwide with more than 1.2 million new cases diagnosed annually. Although extensive progress has been made in the treatment of colorectal cancer, finding novel targets for early diagnosis and effective treatment of these patients is an urgent need. Nuclear factor-erythroid 2–kelch-like ECH-associated protein 1 signaling pathway plays a key role in protecting cells from the damage of intracellular oxidative stress and extracellular oxidizing agents. Nuclear factor-erythroid 2 is a transcription factor that creates intracellular redox homeostasis via transcriptional activity and interaction with kelch-like ECH-associated protein 1. Furthermore, it contributes to survival and chemoresistance of colorectal cancer cells which is mediated by overexpression of cytoprotective and multidrug resistance genes. In this review, the dual role of nuclear factor-erythroid 2 signaling in induction of colorectal cancer cell survival and death as well as the possibility of targeting nuclear factor-erythroid 2–kelch-like ECH-associated protein 1 axis as an advanced strategy in prevention and effective treatment of colorectal cancer patients have been discussed.https://doi.org/10.1177/1010428317705510 |
| spellingShingle | Mohammad Reza Sadeghi Farhad Jeddi Narges Soozangar Mohammad Hossein Somi Nasser Samadi The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance Tumor Biology |
| title | The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance |
| title_full | The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance |
| title_fullStr | The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance |
| title_full_unstemmed | The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance |
| title_short | The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance |
| title_sort | role of nrf2 keap1 axis in colorectal cancer progression and chemoresistance |
| url | https://doi.org/10.1177/1010428317705510 |
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