Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis
Ex vivo surgery and autotransplantation may provide a promising option for radical resection of conventionally unresectable liver tumors. Two cirrhotic patients with hepatocellular carcinoma (HCC), which has an “awkward seat” located in the “intrahepatic vascular triangle area (IVTA)” that consists...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1432274/full |
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| author | Jun-Ze Chen Cheng Zhang Rui-Ling Su Yong-Yuan Jian Kai-Yong Huang Xue-Lin Tan Zhao Chen Yong-Xin Liao Chun-Qiang Dong Kun Dong |
| author_facet | Jun-Ze Chen Cheng Zhang Rui-Ling Su Yong-Yuan Jian Kai-Yong Huang Xue-Lin Tan Zhao Chen Yong-Xin Liao Chun-Qiang Dong Kun Dong |
| author_sort | Jun-Ze Chen |
| collection | DOAJ |
| description | Ex vivo surgery and autotransplantation may provide a promising option for radical resection of conventionally unresectable liver tumors. Two cirrhotic patients with hepatocellular carcinoma (HCC), which has an “awkward seat” located in the “intrahepatic vascular triangle area (IVTA)” that consists of the middle hepatic vein (MHV), the right branches of the Glisson sheath, and the inferior vena cava (IVC), underwent in vivo extended right-half hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation. Innovatively, the outflow of the tumor-free liver was reconstructed ex vivo using pre-frozen allograft blood vessels from brain-dead donors; the patients recovered well postoperation. We report the surgical experience to provide a novel curable surgical procedure for locally advanced IVTA liver tumors. |
| format | Article |
| id | doaj-art-15e4c82b43f04029ac239e343bab4f1f |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-15e4c82b43f04029ac239e343bab4f1f2025-08-20T01:58:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-12-011410.3389/fonc.2024.14322741432274Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosisJun-Ze ChenCheng ZhangRui-Ling SuYong-Yuan JianKai-Yong HuangXue-Lin TanZhao ChenYong-Xin LiaoChun-Qiang DongKun DongEx vivo surgery and autotransplantation may provide a promising option for radical resection of conventionally unresectable liver tumors. Two cirrhotic patients with hepatocellular carcinoma (HCC), which has an “awkward seat” located in the “intrahepatic vascular triangle area (IVTA)” that consists of the middle hepatic vein (MHV), the right branches of the Glisson sheath, and the inferior vena cava (IVC), underwent in vivo extended right-half hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation. Innovatively, the outflow of the tumor-free liver was reconstructed ex vivo using pre-frozen allograft blood vessels from brain-dead donors; the patients recovered well postoperation. We report the surgical experience to provide a novel curable surgical procedure for locally advanced IVTA liver tumors.https://www.frontiersin.org/articles/10.3389/fonc.2024.1432274/fullautotransplantationhepatocellular carcinomahepatectomyin vivoex vivovascular allograft |
| spellingShingle | Jun-Ze Chen Cheng Zhang Rui-Ling Su Yong-Yuan Jian Kai-Yong Huang Xue-Lin Tan Zhao Chen Yong-Xin Liao Chun-Qiang Dong Kun Dong Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis Frontiers in Oncology autotransplantation hepatocellular carcinoma hepatectomy in vivo ex vivo vascular allograft |
| title | Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis |
| title_full | Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis |
| title_fullStr | Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis |
| title_full_unstemmed | Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis |
| title_short | Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis |
| title_sort | case report outflow reconstruction with pre frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis |
| topic | autotransplantation hepatocellular carcinoma hepatectomy in vivo ex vivo vascular allograft |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1432274/full |
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