Iatrogenic Cushing’s syndrome associated with treatment of allergic rhinitis
Iatrogenic Cushing’s syndrome (CS) secondary to intranasal steroid use, although rare, poses significant diagnostic challenges—especially in adults. We present the case of a 40-year-old male who developed CS with hypothalamic-pituitary-adrenal (HPA) axis suppression following prolonged misuse of a d...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Acta Oto-Laryngologica Case Reports |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/23772484.2025.2497534 |
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| author | Yasser AL-Ghabra Mohammed Hamdi Abdulmajeed Yousfan |
| author_facet | Yasser AL-Ghabra Mohammed Hamdi Abdulmajeed Yousfan |
| author_sort | Yasser AL-Ghabra |
| collection | DOAJ |
| description | Iatrogenic Cushing’s syndrome (CS) secondary to intranasal steroid use, although rare, poses significant diagnostic challenges—especially in adults. We present the case of a 40-year-old male who developed CS with hypothalamic-pituitary-adrenal (HPA) axis suppression following prolonged misuse of a dexamethasone nasal spray for allergic rhinitis. His symptoms resolved after discontinuation of the steroid and gradual hydrocortisone tapering. This case underscores the risk of systemic absorption from high-potency steroids such as dexamethasone, even when administered via non-oral routes. While intranasal steroids are considered safe at standard doses, prolonged misuse—particularly of high-potency formulations—may lead to systemic absorption. |
| format | Article |
| id | doaj-art-15d7cbdc3ab34d19b3d7e2022b30186f |
| institution | DOAJ |
| issn | 2377-2484 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Acta Oto-Laryngologica Case Reports |
| spelling | doaj-art-15d7cbdc3ab34d19b3d7e2022b30186f2025-08-20T03:13:22ZengTaylor & Francis GroupActa Oto-Laryngologica Case Reports2377-24842025-12-01101687110.1080/23772484.2025.2497534Iatrogenic Cushing’s syndrome associated with treatment of allergic rhinitisYasser AL-Ghabra0Mohammed Hamdi1Abdulmajeed Yousfan2Department of Otorhinolaryngology, Al-Mouwasat University Hospital, Damascus, SyriaDepartment of Otorhinolaryngology, Al-Mouwasat University Hospital, Damascus, SyriaDepartment of Otorhinolaryngology, Al-Mouwasat University Hospital, Damascus, SyriaIatrogenic Cushing’s syndrome (CS) secondary to intranasal steroid use, although rare, poses significant diagnostic challenges—especially in adults. We present the case of a 40-year-old male who developed CS with hypothalamic-pituitary-adrenal (HPA) axis suppression following prolonged misuse of a dexamethasone nasal spray for allergic rhinitis. His symptoms resolved after discontinuation of the steroid and gradual hydrocortisone tapering. This case underscores the risk of systemic absorption from high-potency steroids such as dexamethasone, even when administered via non-oral routes. While intranasal steroids are considered safe at standard doses, prolonged misuse—particularly of high-potency formulations—may lead to systemic absorption.https://www.tandfonline.com/doi/10.1080/23772484.2025.2497534Allergic rhinitisCushing’s syndromeHPA axis suppressioniatrogenicintranasal steroids |
| spellingShingle | Yasser AL-Ghabra Mohammed Hamdi Abdulmajeed Yousfan Iatrogenic Cushing’s syndrome associated with treatment of allergic rhinitis Acta Oto-Laryngologica Case Reports Allergic rhinitis Cushing’s syndrome HPA axis suppression iatrogenic intranasal steroids |
| title | Iatrogenic Cushing’s syndrome associated with treatment of allergic rhinitis |
| title_full | Iatrogenic Cushing’s syndrome associated with treatment of allergic rhinitis |
| title_fullStr | Iatrogenic Cushing’s syndrome associated with treatment of allergic rhinitis |
| title_full_unstemmed | Iatrogenic Cushing’s syndrome associated with treatment of allergic rhinitis |
| title_short | Iatrogenic Cushing’s syndrome associated with treatment of allergic rhinitis |
| title_sort | iatrogenic cushing s syndrome associated with treatment of allergic rhinitis |
| topic | Allergic rhinitis Cushing’s syndrome HPA axis suppression iatrogenic intranasal steroids |
| url | https://www.tandfonline.com/doi/10.1080/23772484.2025.2497534 |
| work_keys_str_mv | AT yasseralghabra iatrogeniccushingssyndromeassociatedwithtreatmentofallergicrhinitis AT mohammedhamdi iatrogeniccushingssyndromeassociatedwithtreatmentofallergicrhinitis AT abdulmajeedyousfan iatrogeniccushingssyndromeassociatedwithtreatmentofallergicrhinitis |