Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease
Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD). Although the mechanisms of action of NRs in IBD h...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/2624941 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549913730220032 |
|---|---|
| author | Longgui Ning Xinhe Lou Fenming Zhang Guoqiang Xu |
| author_facet | Longgui Ning Xinhe Lou Fenming Zhang Guoqiang Xu |
| author_sort | Longgui Ning |
| collection | DOAJ |
| description | Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD). Although the mechanisms of action of NRs in IBD have not been fully established, accumulating evidence has demonstrated that NRs play complicated roles in regulating intestinal immunity, mucosal barriers, and intestinal flora. As one of the first-line medications for the treatment of IBD, 5-aminosalicylic acid (5-ASA) activates peroxisome proliferator-activated receptor gamma (PPARγ) to attenuate colitis. The protective roles of rifaximin and rifampicin partly depend on promoting pregnane X receptor (PXR) expression. The aims of this review are to discuss the roles of several important NRs, such as PPARγ, PXR, vitamin D receptor (VDR), farnesoid X receptor (FXR), and RAR-related orphan receptor gammat (RORγt), in the pathogenesis of IBD and management strategies based on targeting these receptors. |
| format | Article |
| id | doaj-art-15d7471d49d64befac9556cb636c6e85 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-15d7471d49d64befac9556cb636c6e852025-02-03T06:08:09ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/26249412624941Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel DiseaseLonggui Ning0Xinhe Lou1Fenming Zhang2Guoqiang Xu3Department of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaNuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes. Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD). Although the mechanisms of action of NRs in IBD have not been fully established, accumulating evidence has demonstrated that NRs play complicated roles in regulating intestinal immunity, mucosal barriers, and intestinal flora. As one of the first-line medications for the treatment of IBD, 5-aminosalicylic acid (5-ASA) activates peroxisome proliferator-activated receptor gamma (PPARγ) to attenuate colitis. The protective roles of rifaximin and rifampicin partly depend on promoting pregnane X receptor (PXR) expression. The aims of this review are to discuss the roles of several important NRs, such as PPARγ, PXR, vitamin D receptor (VDR), farnesoid X receptor (FXR), and RAR-related orphan receptor gammat (RORγt), in the pathogenesis of IBD and management strategies based on targeting these receptors.http://dx.doi.org/10.1155/2019/2624941 |
| spellingShingle | Longgui Ning Xinhe Lou Fenming Zhang Guoqiang Xu Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease Mediators of Inflammation |
| title | Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease |
| title_full | Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease |
| title_fullStr | Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease |
| title_full_unstemmed | Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease |
| title_short | Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease |
| title_sort | nuclear receptors in the pathogenesis and management of inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2019/2624941 |
| work_keys_str_mv | AT longguining nuclearreceptorsinthepathogenesisandmanagementofinflammatoryboweldisease AT xinhelou nuclearreceptorsinthepathogenesisandmanagementofinflammatoryboweldisease AT fenmingzhang nuclearreceptorsinthepathogenesisandmanagementofinflammatoryboweldisease AT guoqiangxu nuclearreceptorsinthepathogenesisandmanagementofinflammatoryboweldisease |