Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia

Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia

Ki20227, a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R), has been suggested to regulate microglia inflammatory function and neuronal synaptic plasticity. Triptolide (TP) pretreatment has neuroprotective effects through its anti-inflammatory and antiapoptotic features in ischem...

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Bibliographic Details
Main Authors:	Xiaoxue Du, Feng Gao, Shijia Chen, Benson O. A. Botchway, Nashwa Amin, Zhiying Hu, Marong Fang
Format:	Article
Language:	English
Published:	Wiley 2020-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2020/8796103
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