The role of ubiquitination and deubiquitination in urological tumours
The ubiquitin (Ub) system has been demonstrated to play a crucial role in various cellular processes, including immune responses, cell development, and programmed cell death. Ubiquitination, a form of post-translational modification, occurs in eukaryotic cells and involves several key components, su...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1532878/full |
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| author | Lifeng Gan Lifeng Gan Lifeng Gan Peiyue Luo Peiyue Luo Peiyue Luo Junrong Zou Junrong Zou Wei Li Wei Li Wei Li Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Liying Zheng Biao Qian Biao Qian |
| author_facet | Lifeng Gan Lifeng Gan Lifeng Gan Peiyue Luo Peiyue Luo Peiyue Luo Junrong Zou Junrong Zou Wei Li Wei Li Wei Li Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Liying Zheng Biao Qian Biao Qian |
| author_sort | Lifeng Gan |
| collection | DOAJ |
| description | The ubiquitin (Ub) system has been demonstrated to play a crucial role in various cellular processes, including immune responses, cell development, and programmed cell death. Ubiquitination, a form of post-translational modification, occurs in eukaryotic cells and involves several key components, such as Ub-activating enzymes, Ub-binding enzymes, and Ub-protein ligases. Recently, deubiquitinating enzymes—proteases that reverse the modification of proteins by removing Ub or Ub-like molecules, or by remodeling Ub chains on target proteins—have been identified as significant regulators of ubiquitination-mediated degradation. These enzymes profoundly influence cellular pathways and numerous biological processes, including the DNA damage response and DNA repair mechanisms. Recent studies increasingly demonstrate a relationship between ubiquitination, deubiquitination, and urinary diseases. The roles of these processes in urinary diseases are complex, encompassing various aspects of signaling, protein stability, and cellular metabolism. As research advances, the specific mechanisms by which these processes influence urologic diseases will be further clarified. This review examines recent discoveries in this field, aiming to provide new strategies and targets for the diagnosis and treatment of urologic diseases. |
| format | Article |
| id | doaj-art-15d40f53f26244c2ac07a77ebafa72d6 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-15d40f53f26244c2ac07a77ebafa72d62025-08-20T03:13:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.15328781532878The role of ubiquitination and deubiquitination in urological tumoursLifeng Gan0Lifeng Gan1Lifeng Gan2Peiyue Luo3Peiyue Luo4Peiyue Luo5Junrong Zou6Junrong Zou7Wei Li8Wei Li9Wei Li10Qi Chen11Qi Chen12Qi Chen13Le Cheng14Le Cheng15Le Cheng16Fangtao Zhang17Fangtao Zhang18Fangtao Zhang19Haidong Zhong20Haidong Zhong21Haidong Zhong22Liying Zheng23Biao Qian24Biao Qian25The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaDepartment of Graduate, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaKey Laboratory of Urology and Andrology of Ganzhou, Ganzhou, Jiangxi, ChinaThe ubiquitin (Ub) system has been demonstrated to play a crucial role in various cellular processes, including immune responses, cell development, and programmed cell death. Ubiquitination, a form of post-translational modification, occurs in eukaryotic cells and involves several key components, such as Ub-activating enzymes, Ub-binding enzymes, and Ub-protein ligases. Recently, deubiquitinating enzymes—proteases that reverse the modification of proteins by removing Ub or Ub-like molecules, or by remodeling Ub chains on target proteins—have been identified as significant regulators of ubiquitination-mediated degradation. These enzymes profoundly influence cellular pathways and numerous biological processes, including the DNA damage response and DNA repair mechanisms. Recent studies increasingly demonstrate a relationship between ubiquitination, deubiquitination, and urinary diseases. The roles of these processes in urinary diseases are complex, encompassing various aspects of signaling, protein stability, and cellular metabolism. As research advances, the specific mechanisms by which these processes influence urologic diseases will be further clarified. This review examines recent discoveries in this field, aiming to provide new strategies and targets for the diagnosis and treatment of urologic diseases.https://www.frontiersin.org/articles/10.3389/fphar.2025.1532878/fullubiquitinationdeubiquitinationurinary systemmolecular mechanismstargeted therapy |
| spellingShingle | Lifeng Gan Lifeng Gan Lifeng Gan Peiyue Luo Peiyue Luo Peiyue Luo Junrong Zou Junrong Zou Wei Li Wei Li Wei Li Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Liying Zheng Biao Qian Biao Qian The role of ubiquitination and deubiquitination in urological tumours Frontiers in Pharmacology ubiquitination deubiquitination urinary system molecular mechanisms targeted therapy |
| title | The role of ubiquitination and deubiquitination in urological tumours |
| title_full | The role of ubiquitination and deubiquitination in urological tumours |
| title_fullStr | The role of ubiquitination and deubiquitination in urological tumours |
| title_full_unstemmed | The role of ubiquitination and deubiquitination in urological tumours |
| title_short | The role of ubiquitination and deubiquitination in urological tumours |
| title_sort | role of ubiquitination and deubiquitination in urological tumours |
| topic | ubiquitination deubiquitination urinary system molecular mechanisms targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1532878/full |
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