Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healing
The wound of diabetes is closely related to inflammation, reactive oxygen species production, impaired angiogenesis and bacterial infection. It is urgent to develop a hydrogel dressing with antibacterial and anti-inflammatory properties and promoting angiogenesis to achieve efficient wound healing....
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| Format: | Article |
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Elsevier
2025-06-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525005489 |
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| author | Ruping Li Yanxin Wu Lvchen He Ruotong Yang Kaipei Luo Fei Gao Haipo Yuan Yu Zheng Yao He |
| author_facet | Ruping Li Yanxin Wu Lvchen He Ruotong Yang Kaipei Luo Fei Gao Haipo Yuan Yu Zheng Yao He |
| author_sort | Ruping Li |
| collection | DOAJ |
| description | The wound of diabetes is closely related to inflammation, reactive oxygen species production, impaired angiogenesis and bacterial infection. It is urgent to develop a hydrogel dressing with antibacterial and anti-inflammatory properties and promoting angiogenesis to achieve efficient wound healing. Carboxymethyl chitosan (CMCS) is obtained by chemical modification of chitosan, which has excellent biocompatibility and rapid gel properties. Deferiptyline (DFO) has the ability to increase the expression of HIF-1α, which promotes the release of endogenous growth factors related to angiogenesis. Luteolin (LUT), the active ingredient of traditional Chinese medicine, shows unique advantages in treating diabetes wounds. In this study, polysaccharide hydrogel prepared by combining DFO and LUT has excellent antibacterial and antioxidant properties, promotes cell migration, releases LUT and DFO at the wound site, and enhances angiogenesis through HIF-1α and VEGFA pathways. The hydrogel synergistically promotes cell migration, angiogenesis and effectively eliminates drug-resistant bacteria, which is beneficial to wound healing of diabetes. This study has created a multifunctional hydrogel loaded with DFO and crosslinked polysaccharide, an active ingredient of traditional Chinese medicine, with sustained release, enhanced permeability and great biocompatibility, which can be used as an excellent antibacterial dressing for diabetes wounds. |
| format | Article |
| id | doaj-art-15d018ddfae0410b95338cd9fdb1da7f |
| institution | OA Journals |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-15d018ddfae0410b95338cd9fdb1da7f2025-08-20T02:35:44ZengElsevierMaterials & Design0264-12752025-06-0125411412810.1016/j.matdes.2025.114128Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healingRuping Li0Yanxin Wu1Lvchen He2Ruotong Yang3Kaipei Luo4Fei Gao5Haipo Yuan6Yu Zheng7Yao He8School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratoryof Southwestern Chinese Medicine Resources, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratoryof Southwestern Chinese Medicine Resources, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratoryof Southwestern Chinese Medicine Resources, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratoryof Southwestern Chinese Medicine Resources, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratoryof Southwestern Chinese Medicine Resources, Chengdu 611137, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratoryof Southwestern Chinese Medicine Resources, Chengdu 611137, ChinaDepartment of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China; Corresponding authors at: Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Sichuan Clinical Research Center for Nephropathy, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Luzhou, Sichuan 646000, China.Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou 646000, China; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou 646000, China; Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Luzhou 646000, China; Corresponding authors at: Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Sichuan Clinical Research Center for Nephropathy, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Luzhou, Sichuan 646000, China.School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratoryof Southwestern Chinese Medicine Resources, Chengdu 611137, China; Corresponding authors at: Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Sichuan Clinical Research Center for Nephropathy, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Luzhou, Sichuan 646000, China.The wound of diabetes is closely related to inflammation, reactive oxygen species production, impaired angiogenesis and bacterial infection. It is urgent to develop a hydrogel dressing with antibacterial and anti-inflammatory properties and promoting angiogenesis to achieve efficient wound healing. Carboxymethyl chitosan (CMCS) is obtained by chemical modification of chitosan, which has excellent biocompatibility and rapid gel properties. Deferiptyline (DFO) has the ability to increase the expression of HIF-1α, which promotes the release of endogenous growth factors related to angiogenesis. Luteolin (LUT), the active ingredient of traditional Chinese medicine, shows unique advantages in treating diabetes wounds. In this study, polysaccharide hydrogel prepared by combining DFO and LUT has excellent antibacterial and antioxidant properties, promotes cell migration, releases LUT and DFO at the wound site, and enhances angiogenesis through HIF-1α and VEGFA pathways. The hydrogel synergistically promotes cell migration, angiogenesis and effectively eliminates drug-resistant bacteria, which is beneficial to wound healing of diabetes. This study has created a multifunctional hydrogel loaded with DFO and crosslinked polysaccharide, an active ingredient of traditional Chinese medicine, with sustained release, enhanced permeability and great biocompatibility, which can be used as an excellent antibacterial dressing for diabetes wounds.http://www.sciencedirect.com/science/article/pii/S0264127525005489CMCSDiabetic WoundWound dressings |
| spellingShingle | Ruping Li Yanxin Wu Lvchen He Ruotong Yang Kaipei Luo Fei Gao Haipo Yuan Yu Zheng Yao He Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healing Materials & Design CMCS Diabetic Wound Wound dressings |
| title | Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healing |
| title_full | Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healing |
| title_fullStr | Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healing |
| title_full_unstemmed | Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healing |
| title_short | Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healing |
| title_sort | chinese herb crosslinked polysaccharide hydrogel loading dfo accelerates diabetes wound healing |
| topic | CMCS Diabetic Wound Wound dressings |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525005489 |
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