Terahertz metasensor with pseudo parity time symmetry for oral cancer diagnostics
Abstract This study presents the design and theoretical analysis of a pseudo parity-time symmetric photonic crystal biosensor for early oral cancer detection. Using the transfer matrix method, we numerically investigated the resonant transmission properties of a 1D photonic crystal structure with a...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-14176-9 |
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| Summary: | Abstract This study presents the design and theoretical analysis of a pseudo parity-time symmetric photonic crystal biosensor for early oral cancer detection. Using the transfer matrix method, we numerically investigated the resonant transmission properties of a 1D photonic crystal structure with a central defect layer (D = 50 μm) containing healthy and cancer oral cells. The proposed $$\:{\left(Si{O}_{2}*Si\right)}^{N}\left(oral\:cells\right){\left(Si{O}_{2}*Si\right)}^{N}*substrate$$ configuration exhibits exceptional sensitivity, quantified by two key metrics: a spectral sensitivity of 118 GHz/RIU and an extraordinary transmittance sensitivity of $$\:1.9\times\:{10}^{8}\:\%/RIU.$$ These results demonstrate significant improvements over conventional photonic biosensors, enabled by the PT-symmetric design’s ability to operate near an exceptional point. The optimized structure achieves ultra-sharp resonances ( $$\:9.1\times\:{10}^{-5}$$ THz FWHM) with remarkable field enhancement, making it particularly suitable for detecting minute refractive index changes associated with malignant transformations. Our findings establish a foundation for developing high-performance, label-free diagnostic tools for early-stage oral cancer detection. |
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| ISSN: | 2045-2322 |