COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACE
Aim. To compare effects of 12-month monotherapy with nebivolol, enalapril and indapamide on blood pressure (BP), left ventricular hypertrophy and quality of life in the locomotive engineers and their assistants with stress-associated hypertension at the work place (HTwp).Material and methods. 96 loc...
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1044 |
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| author | О. N. Antropova I. V. Osipova E. I. Kuznetzova N. V. Piricova I. I. Curbatova |
| author_facet | О. N. Antropova I. V. Osipova E. I. Kuznetzova N. V. Piricova I. I. Curbatova |
| author_sort | О. N. Antropova |
| collection | DOAJ |
| description | Aim. To compare effects of 12-month monotherapy with nebivolol, enalapril and indapamide on blood pressure (BP), left ventricular hypertrophy and quality of life in the locomotive engineers and their assistants with stress-associated hypertension at the work place (HTwp).Material and methods. 96 locomotive engineers (20- 53 y.o) and their assistants with HTwp were observed. The patients were randomized to receive nebivolol (1 group), enalapril (2 group) or indapamide (3 group). 24-hour BP monitoring, echocardiography and quality of life interview with SF–36 questionnaire were performed at the start and after 12 months of the treatment.Results. Long-term therapy lead to achievement of target BP level, improved quality of life and reduced in left ventricular hypertrophy in patients with HTwp. Nebivolol reduced systolic “BP load” more significantly than indapamide did, exerted favorable influence on circadian BP rhythm and reduced heart rate. Monotherapy with nebivolol showed benefits in effect on quality of life.Conclusion. Nebivolol has some advantages in comparison with indapamide and enalapril in antihypertensive therapy of patients with stress-associated HT. |
| format | Article |
| id | doaj-art-15cbb54c67be44a89ec8d09f3083a6db |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-15cbb54c67be44a89ec8d09f3083a6db2025-08-23T10:00:25ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0141141810.20996/1819-6446-2008-4-1-98-1031043COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACEО. N. Antropova0I. V. Osipova1E. I. Kuznetzova2N. V. Piricova3I. I. Curbatova4Altay State Medical UniversityAltay State Medical UniversityAltay State Medical UniversityAltay State Medical UniversityRailway Division clinical Hospital at Barnaul stationAim. To compare effects of 12-month monotherapy with nebivolol, enalapril and indapamide on blood pressure (BP), left ventricular hypertrophy and quality of life in the locomotive engineers and their assistants with stress-associated hypertension at the work place (HTwp).Material and methods. 96 locomotive engineers (20- 53 y.o) and their assistants with HTwp were observed. The patients were randomized to receive nebivolol (1 group), enalapril (2 group) or indapamide (3 group). 24-hour BP monitoring, echocardiography and quality of life interview with SF–36 questionnaire were performed at the start and after 12 months of the treatment.Results. Long-term therapy lead to achievement of target BP level, improved quality of life and reduced in left ventricular hypertrophy in patients with HTwp. Nebivolol reduced systolic “BP load” more significantly than indapamide did, exerted favorable influence on circadian BP rhythm and reduced heart rate. Monotherapy with nebivolol showed benefits in effect on quality of life.Conclusion. Nebivolol has some advantages in comparison with indapamide and enalapril in antihypertensive therapy of patients with stress-associated HT.https://www.rpcardio.online/jour/article/view/1044arterial hypertension24-hour blood pressure monitoringquality of life |
| spellingShingle | О. N. Antropova I. V. Osipova E. I. Kuznetzova N. V. Piricova I. I. Curbatova COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACE Рациональная фармакотерапия в кардиологии arterial hypertension 24-hour blood pressure monitoring quality of life |
| title | COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACE |
| title_full | COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACE |
| title_fullStr | COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACE |
| title_full_unstemmed | COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACE |
| title_short | COMPARATIVE EFFICACY OF LONG-TERM ANTIHYPERTENSIVE MONOTHERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AT THE WORK PLACE |
| title_sort | comparative efficacy of long term antihypertensive monotherapy in patients with arterial hypertension at the work place |
| topic | arterial hypertension 24-hour blood pressure monitoring quality of life |
| url | https://www.rpcardio.online/jour/article/view/1044 |
| work_keys_str_mv | AT onantropova comparativeefficacyoflongtermantihypertensivemonotherapyinpatientswitharterialhypertensionattheworkplace AT ivosipova comparativeefficacyoflongtermantihypertensivemonotherapyinpatientswitharterialhypertensionattheworkplace AT eikuznetzova comparativeefficacyoflongtermantihypertensivemonotherapyinpatientswitharterialhypertensionattheworkplace AT nvpiricova comparativeefficacyoflongtermantihypertensivemonotherapyinpatientswitharterialhypertensionattheworkplace AT iicurbatova comparativeefficacyoflongtermantihypertensivemonotherapyinpatientswitharterialhypertensionattheworkplace |