IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue

IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue

Abstract Familial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Even among carriers of the same genetic variant, duodenal phenotypes vary, indicating that additional factors, such as the local immune system, play a role. We observe...

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Main Authors: Kim M. Kaiser, Jan Raabe, Michael ToVinh, Gudrun Hack, Sarah Ahmad, Niko Müller, Julia Cassella, Sofia I. Walravens, Paula Alfaro, Lauren Arias Garcia, Dominik J. Kaczmarek, Tim Marwitz, Felix Goeser, Hans Dieter Nischalke, Philipp Lutz, Nils Sommer, Tim Vilz, Marieta Toma, Susanne Steiner, Oliver Hommerding, Johannes Oldenburg, Michael Hölzel, Sebastian Kadzik, Alexander Maas, Jonas Eckrich, Philipp Zumfelde, Farhad Shakeri, Svetozar Nesic, Andreas Buness, Emilia De Caro, Matthias Becker, Marc D. Beyer, Thomas Ulas, Anna C. Aschenbrenner, Lisa M. Steinheuer, Kevin Thurley, Sandy Kroh, Ralf Uecker, Anja E. Hauser, Florian N. Gohr, Florian I. Schmidt, Danni Wang, Kathrin Held, Olga Baranov, Christof Geldmacher, Christian P. Strassburg, Robert Hüneburg, Benjamin Krämer, Jacob Nattermann
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58907-y
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