High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence
ABSTRACT Dietary manipulations like ketogenic diets are established interventions for recalcitrant epilepsy. However, it remains unknown whether specific macronutrient exposure through dietary environments could possibly extend to primary preventive qualities, associated with changes in epilepsy dis...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70017 |
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| author | Duan Ni Alistair Senior David Raubenheimer Stephen J. Simpson Ralph Nanan |
| author_facet | Duan Ni Alistair Senior David Raubenheimer Stephen J. Simpson Ralph Nanan |
| author_sort | Duan Ni |
| collection | DOAJ |
| description | ABSTRACT Dietary manipulations like ketogenic diets are established interventions for recalcitrant epilepsy. However, it remains unknown whether specific macronutrient exposure through dietary environments could possibly extend to primary preventive qualities, associated with changes in epilepsy disease burden (prevalence and incidence). Here, macronutrient supply, GDP, and idiopathic epilepsy disease burden data were collated from more than 150 countries from 1990 to 2018. Nutritional geometry generalized additive mixed models (GAMMs) modeling unraveled that dietary environments with high‐fat and low‐carbohydrate supplies were linked to lower epilepsy incidence and prevalence. Our analyses suggested a plausible primary preventive role of dietary manipulations for epilepsy. |
| format | Article |
| id | doaj-art-15ca6576bea34af4a681d067cabe818d |
| institution | OA Journals |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-15ca6576bea34af4a681d067cabe818d2025-08-20T02:25:34ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-05-011251077108110.1002/acn3.70017High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and PrevalenceDuan Ni0Alistair Senior1David Raubenheimer2Stephen J. Simpson3Ralph Nanan4Sydney Medical School Nepean The University of Sydney Sydney New South Wales AustraliaCharles Perkins Centre The University of Sydney Sydney New South Wales AustraliaCharles Perkins Centre The University of Sydney Sydney New South Wales AustraliaCharles Perkins Centre The University of Sydney Sydney New South Wales AustraliaSydney Medical School Nepean The University of Sydney Sydney New South Wales AustraliaABSTRACT Dietary manipulations like ketogenic diets are established interventions for recalcitrant epilepsy. However, it remains unknown whether specific macronutrient exposure through dietary environments could possibly extend to primary preventive qualities, associated with changes in epilepsy disease burden (prevalence and incidence). Here, macronutrient supply, GDP, and idiopathic epilepsy disease burden data were collated from more than 150 countries from 1990 to 2018. Nutritional geometry generalized additive mixed models (GAMMs) modeling unraveled that dietary environments with high‐fat and low‐carbohydrate supplies were linked to lower epilepsy incidence and prevalence. Our analyses suggested a plausible primary preventive role of dietary manipulations for epilepsy.https://doi.org/10.1002/acn3.70017dietary environmenthigh‐fat low‐carbohydrateidiopathic epilepsymacronutrient |
| spellingShingle | Duan Ni Alistair Senior David Raubenheimer Stephen J. Simpson Ralph Nanan High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence Annals of Clinical and Translational Neurology dietary environment high‐fat low‐carbohydrate idiopathic epilepsy macronutrient |
| title | High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence |
| title_full | High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence |
| title_fullStr | High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence |
| title_full_unstemmed | High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence |
| title_short | High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence |
| title_sort | high fat and low carbohydrate dietary environments are linked to reduced idiopathic epilepsy incidence and prevalence |
| topic | dietary environment high‐fat low‐carbohydrate idiopathic epilepsy macronutrient |
| url | https://doi.org/10.1002/acn3.70017 |
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