The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol
Abstract Determining the genetic contributions to Parkinson’s disease (PD) across diverse ancestries is a high priority as this work can guide therapeutic development in a global setting. The genetics of PD spans the etiological risk spectrum, from rare, highly deleterious variants linked to monogen...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-10-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-024-03914-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850204500607893504 |
|---|---|
| author | Lana M. Chahine Naomi Louie J Solle Fulya Akçimen Andrew Ameri Samantha Augenbraun Sabrina Avripas Sarah Breaux Christopher Causey Shivika Chandra Marissa Dean Elizabeth A. Disbrow Lauren Fanty Jessica Fernandez Erin R. Foster Erin Furr Stimming Deborah Hall Vanessa Hinson Ashani Johnson-Turbes Cabell Jonas Camilla Kilbane Scott A. Norris Bao-Tran Nguyen Mahesh Padmanaban Kimberly Paquette Carly Parry Natalia Pessoa Rocha Ashley Rawls Ejaz A. Shamim Lisa M. Shulman Rebeka Sipma Julia Staisch Rami Traurig Rainer von Coelln Peter Wild Crea Tao Xie Zih-Hua Fang Alyssa O’Grady Catherine M. Kopil Maggie McGuire Kuhl Andrew Singleton Cornelis Blauwendraat Sara Bandres-Ciga the BLAAC PD Study and the Global Parkinson’s Genetics Program (GP2) |
| author_facet | Lana M. Chahine Naomi Louie J Solle Fulya Akçimen Andrew Ameri Samantha Augenbraun Sabrina Avripas Sarah Breaux Christopher Causey Shivika Chandra Marissa Dean Elizabeth A. Disbrow Lauren Fanty Jessica Fernandez Erin R. Foster Erin Furr Stimming Deborah Hall Vanessa Hinson Ashani Johnson-Turbes Cabell Jonas Camilla Kilbane Scott A. Norris Bao-Tran Nguyen Mahesh Padmanaban Kimberly Paquette Carly Parry Natalia Pessoa Rocha Ashley Rawls Ejaz A. Shamim Lisa M. Shulman Rebeka Sipma Julia Staisch Rami Traurig Rainer von Coelln Peter Wild Crea Tao Xie Zih-Hua Fang Alyssa O’Grady Catherine M. Kopil Maggie McGuire Kuhl Andrew Singleton Cornelis Blauwendraat Sara Bandres-Ciga the BLAAC PD Study and the Global Parkinson’s Genetics Program (GP2) |
| author_sort | Lana M. Chahine |
| collection | DOAJ |
| description | Abstract Determining the genetic contributions to Parkinson’s disease (PD) across diverse ancestries is a high priority as this work can guide therapeutic development in a global setting. The genetics of PD spans the etiological risk spectrum, from rare, highly deleterious variants linked to monogenic forms with Mendelian patterns of inheritance, to common variation involved in sporadic disease. A major limitation in PD genomics research is lack of racial and ethnic diversity. Enrollment disparities have detrimental consequences on the generalizability of results and exacerbate existing inequities in care. The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study is part of the Global Parkinson’s Genetics Program, supported by the Aligning Science Across Parkinson’s initiative. The goal of the study is to investigate the genetic architecture underlying PD risk and progression in the Black and/or African American populations. This cross-sectional multicenter study in the United States has a recruitment target of up to 2,000 individuals with PD and up to 2,000 controls, all of Black and/or African American ancestry. The study design incorporates several strategies to reduce barriers to research participation. The multifaceted recruitment strategy aims to involve individuals with and without PD in various settings, emphasizing community outreach and engagement. The BLAAC PD study is an important first step toward informing understanding of the genetics of PD in a more diverse population. |
| format | Article |
| id | doaj-art-15c7bceb54b1476f84c1fdcc646a1eef |
| institution | OA Journals |
| issn | 1471-2377 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-15c7bceb54b1476f84c1fdcc646a1eef2025-08-20T02:11:17ZengBMCBMC Neurology1471-23772024-10-0124111510.1186/s12883-024-03914-7The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocolLana M. Chahine0Naomi Louie1J Solle2Fulya Akçimen3Andrew Ameri4Samantha Augenbraun5Sabrina Avripas6Sarah Breaux7Christopher Causey8Shivika Chandra9Marissa Dean10Elizabeth A. Disbrow11Lauren Fanty12Jessica Fernandez13Erin R. Foster14Erin Furr Stimming15Deborah Hall16Vanessa Hinson17Ashani Johnson-Turbes18Cabell Jonas19Camilla Kilbane20Scott A. Norris21Bao-Tran Nguyen22Mahesh Padmanaban23Kimberly Paquette24Carly Parry25Natalia Pessoa Rocha26Ashley Rawls27Ejaz A. Shamim28Lisa M. Shulman29Rebeka Sipma30Julia Staisch31Rami Traurig32Rainer von Coelln33Peter Wild Crea34Tao Xie35Zih-Hua Fang36Alyssa O’Grady37Catherine M. Kopil38Maggie McGuire Kuhl39Andrew Singleton40Cornelis Blauwendraat41Sara Bandres-Ciga42the BLAAC PD Study and the Global Parkinson’s Genetics Program (GP2)University of PittsburghThe Michael J. Fox Foundation for Parkinson’s ResearchThe Michael J. Fox Foundation for Parkinson’s ResearchLaboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthMedical University of South CarolinaNORC at the University of ChicagoNORC at the University of ChicagoOchsner Clinic FoundationLouisiana State University Health Sciences Center ShreveportThe University of Texas Health Science Center at HoustonUniversity of Alabama at BirminghamLouisiana State University Health Sciences Center ShreveportUniversity of FloridaNORC at the University of ChicagoUniversity of PittsburghThe University of Texas Health Science Center at HoustonRush University Medical CenterMedical University of South CarolinaNORC at the University of ChicagoKaiser Permanente Mid-Atlantic StatesUniversity Hospitals Cleveland Medical CenterWashington University in St. LouisNORC at the University of ChicagoUniversity of ChicagoCenter for Alzheimer’s Disease and Related Dementias, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institutes of HealthNORC at the University of ChicagoThe University of Texas Health Science Center at HoustonUniversity of FloridaKaiser Permanente Mid-Atlantic StatesUniversity of MarylandUniversity of Alabama at BirminghamOchsner Clinic FoundationCenter for Alzheimer’s Disease and Related Dementias, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institutes of HealthUniversity of MarylandCenter for Alzheimer’s Disease and Related Dementias, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institutes of HealthUniversity of ChicagoGerman Center for Neurodegenerative Diseases (DZNE)The Michael J. Fox Foundation for Parkinson’s ResearchThe Michael J. Fox Foundation for Parkinson’s ResearchThe Michael J. Fox Foundation for Parkinson’s ResearchLaboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthCoalition for Aligning ScienceCenter for Alzheimer’s Disease and Related Dementias, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institutes of HealthAbstract Determining the genetic contributions to Parkinson’s disease (PD) across diverse ancestries is a high priority as this work can guide therapeutic development in a global setting. The genetics of PD spans the etiological risk spectrum, from rare, highly deleterious variants linked to monogenic forms with Mendelian patterns of inheritance, to common variation involved in sporadic disease. A major limitation in PD genomics research is lack of racial and ethnic diversity. Enrollment disparities have detrimental consequences on the generalizability of results and exacerbate existing inequities in care. The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study is part of the Global Parkinson’s Genetics Program, supported by the Aligning Science Across Parkinson’s initiative. The goal of the study is to investigate the genetic architecture underlying PD risk and progression in the Black and/or African American populations. This cross-sectional multicenter study in the United States has a recruitment target of up to 2,000 individuals with PD and up to 2,000 controls, all of Black and/or African American ancestry. The study design incorporates several strategies to reduce barriers to research participation. The multifaceted recruitment strategy aims to involve individuals with and without PD in various settings, emphasizing community outreach and engagement. The BLAAC PD study is an important first step toward informing understanding of the genetics of PD in a more diverse population.https://doi.org/10.1186/s12883-024-03914-7Parkinson’s diseaseGeneticsRiskRacial health disparitiesAfrican American ancestryAfrican admixed |
| spellingShingle | Lana M. Chahine Naomi Louie J Solle Fulya Akçimen Andrew Ameri Samantha Augenbraun Sabrina Avripas Sarah Breaux Christopher Causey Shivika Chandra Marissa Dean Elizabeth A. Disbrow Lauren Fanty Jessica Fernandez Erin R. Foster Erin Furr Stimming Deborah Hall Vanessa Hinson Ashani Johnson-Turbes Cabell Jonas Camilla Kilbane Scott A. Norris Bao-Tran Nguyen Mahesh Padmanaban Kimberly Paquette Carly Parry Natalia Pessoa Rocha Ashley Rawls Ejaz A. Shamim Lisa M. Shulman Rebeka Sipma Julia Staisch Rami Traurig Rainer von Coelln Peter Wild Crea Tao Xie Zih-Hua Fang Alyssa O’Grady Catherine M. Kopil Maggie McGuire Kuhl Andrew Singleton Cornelis Blauwendraat Sara Bandres-Ciga the BLAAC PD Study and the Global Parkinson’s Genetics Program (GP2) The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol BMC Neurology Parkinson’s disease Genetics Risk Racial health disparities African American ancestry African admixed |
| title | The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol |
| title_full | The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol |
| title_fullStr | The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol |
| title_full_unstemmed | The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol |
| title_short | The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol |
| title_sort | black and african american connections to parkinson s disease blaac pd study protocol |
| topic | Parkinson’s disease Genetics Risk Racial health disparities African American ancestry African admixed |
| url | https://doi.org/10.1186/s12883-024-03914-7 |
| work_keys_str_mv | AT lanamchahine theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT naomilouie theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT jsolle theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT fulyaakcimen theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT andrewameri theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT samanthaaugenbraun theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT sabrinaavripas theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT sarahbreaux theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT christophercausey theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT shivikachandra theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT marissadean theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT elizabethadisbrow theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT laurenfanty theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT jessicafernandez theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT erinrfoster theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT erinfurrstimming theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT deborahhall theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT vanessahinson theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT ashanijohnsonturbes theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT cabelljonas theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT camillakilbane theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT scottanorris theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT baotrannguyen theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT maheshpadmanaban theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT kimberlypaquette theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT carlyparry theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT nataliapessoarocha theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT ashleyrawls theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT ejazashamim theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT lisamshulman theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT rebekasipma theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT juliastaisch theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT ramitraurig theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT rainervoncoelln theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT peterwildcrea theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT taoxie theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT zihhuafang theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT alyssaogrady theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT catherinemkopil theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT maggiemcguirekuhl theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT andrewsingleton theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT cornelisblauwendraat theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT sarabandresciga theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT theblaacpdstudyandtheglobalparkinsonsgeneticsprogramgp2 theblackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT lanamchahine blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT naomilouie blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT jsolle blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT fulyaakcimen blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT andrewameri blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT samanthaaugenbraun blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT sabrinaavripas blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT sarahbreaux blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT christophercausey blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT shivikachandra blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT marissadean blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT elizabethadisbrow blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT laurenfanty blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT jessicafernandez blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT erinrfoster blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT erinfurrstimming blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT deborahhall blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT vanessahinson blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT ashanijohnsonturbes blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT cabelljonas blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT camillakilbane blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT scottanorris blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT baotrannguyen blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT maheshpadmanaban blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT kimberlypaquette blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT carlyparry blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT nataliapessoarocha blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT ashleyrawls blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT ejazashamim blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT lisamshulman blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT rebekasipma blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT juliastaisch blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT ramitraurig blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT rainervoncoelln blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT peterwildcrea blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT taoxie blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT zihhuafang blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT alyssaogrady blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT catherinemkopil blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT maggiemcguirekuhl blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT andrewsingleton blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT cornelisblauwendraat blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT sarabandresciga blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol AT theblaacpdstudyandtheglobalparkinsonsgeneticsprogramgp2 blackandafricanamericanconnectionstoparkinsonsdiseaseblaacpdstudyprotocol |