Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia
This case report explores the therapeutic potential of lymphovenous bypass (LVB) surgery performed at the neck in neurodegenerative diseases, specifically Alzheimer's disease (AD) dementia. The subject is a 58-year-old woman who was previously healthy but began experiencing unexplained memory d...
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2025-07-01
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| Series: | Archives of Plastic Surgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2627-9243 |
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| author | Qingping Xie Changsik John Pak Jingeun Kwon Sung-Chuan Chao Joon Pio Hong |
| author_facet | Qingping Xie Changsik John Pak Jingeun Kwon Sung-Chuan Chao Joon Pio Hong |
| author_sort | Qingping Xie |
| collection | DOAJ |
| description | This case report explores the therapeutic potential of lymphovenous bypass (LVB) surgery performed at the neck in neurodegenerative diseases, specifically Alzheimer's disease (AD) dementia. The subject is a 58-year-old woman who was previously healthy but began experiencing unexplained memory decline and frequent disorientation in the past 7 years, leading to an AD diagnosis. Despite ongoing pharmaceutical therapy, her symptoms progressed to severe dementia accompanied by behavioral and psychological symptoms of dementia (BPSD). Her Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores were both 0/30, and 18F-AV-45 PET/CT revealed abnormal brain amyloid load. For salvage therapy, she underwent LVBs on her neck bilaterally. Postoperatively, she got better MMSE and MoCA scores with dramatic improvement in communication and activity. 18F-AV-45 PET/CT scans 4 months after surgery indicated a reduction in abnormal brain amyloid deposits. This case report highlights the potential effectiveness of LVB surgery in reducing brain amyloid load and attenuating cognitive impairment and BPSD. Further research with animal experiments and clinical trials is necessary to confirm these findings. |
| format | Article |
| id | doaj-art-15c6f229f25f46ff9c6233eb37e7e882 |
| institution | DOAJ |
| issn | 2234-6163 2234-6171 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj-art-15c6f229f25f46ff9c6233eb37e7e8822025-08-20T02:48:18ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712025-07-01520424725210.1055/a-2627-9243Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease DementiaQingping Xie0https://orcid.org/0009-0009-5980-2431Changsik John Pak1https://orcid.org/0000-0002-3477-7120Jingeun Kwon2https://orcid.org/0000-0002-5873-3077Sung-Chuan Chao3https://orcid.org/0000-0002-5758-0494Joon Pio Hong4https://orcid.org/0000-0002-6208-9704Department of Plastic and Reconstructive Surgery, Hangzhou Qiushi Hospital, Hangzhou, Zhejiang, People's Republic of ChinaDepartment of Plastic and Reconstructive Surgery, University of Ulsan, College of Medicine, Seoul Asan Medical Center, Seoul, Korea (the Republic of)Department of Plastic and Reconstructive Surgery, University of Ulsan, College of Medicine, Seoul Asan Medical Center, Seoul, Korea (the Republic of)Department of Traumatology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Plastic and Reconstructive Surgery, University of Ulsan, College of Medicine, Seoul Asan Medical Center, Seoul, Korea (the Republic of)This case report explores the therapeutic potential of lymphovenous bypass (LVB) surgery performed at the neck in neurodegenerative diseases, specifically Alzheimer's disease (AD) dementia. The subject is a 58-year-old woman who was previously healthy but began experiencing unexplained memory decline and frequent disorientation in the past 7 years, leading to an AD diagnosis. Despite ongoing pharmaceutical therapy, her symptoms progressed to severe dementia accompanied by behavioral and psychological symptoms of dementia (BPSD). Her Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores were both 0/30, and 18F-AV-45 PET/CT revealed abnormal brain amyloid load. For salvage therapy, she underwent LVBs on her neck bilaterally. Postoperatively, she got better MMSE and MoCA scores with dramatic improvement in communication and activity. 18F-AV-45 PET/CT scans 4 months after surgery indicated a reduction in abnormal brain amyloid deposits. This case report highlights the potential effectiveness of LVB surgery in reducing brain amyloid load and attenuating cognitive impairment and BPSD. Further research with animal experiments and clinical trials is necessary to confirm these findings.http://www.thieme-connect.de/DOI/DOI?10.1055/a-2627-9243Alzheimer's diseasedementiabehavioral and psychological symptomsbrain lymphaticslymphovenous bypass |
| spellingShingle | Qingping Xie Changsik John Pak Jingeun Kwon Sung-Chuan Chao Joon Pio Hong Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia Archives of Plastic Surgery Alzheimer's disease dementia behavioral and psychological symptoms brain lymphatics lymphovenous bypass |
| title | Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia |
| title_full | Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia |
| title_fullStr | Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia |
| title_full_unstemmed | Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia |
| title_short | Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia |
| title_sort | potential role of lymphovenous bypass in mitigating alzheimer s disease dementia |
| topic | Alzheimer's disease dementia behavioral and psychological symptoms brain lymphatics lymphovenous bypass |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2627-9243 |
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