TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice

TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice

Abstract TAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregulation of metabolism and emotion is shared across these disorders and may be caused by hypothalam...

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Bibliographic Details
Main Authors: Sofia Bergh, Nicolas Casadei, Sanaz Gabery, Oskar Simonsson, João M. N. Duarte, Deniz Kirik, Huu Phuc Nguyen, Åsa Petersén
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
(4 to 6): TDP-43
Hypothalamus
Metabolism
Amyotrophic lateral sclerosis
Frontotemporal dementia
Online Access:https://doi.org/10.1186/s40478-025-02018-8
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