Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature
Objective. To evaluate maternal and fetal outcomes in pregnant patients with fibrodysplasia ossificans progressiva (FOP; OMIM#135100), an ultrarare genetic disorder characterized by progressive heterotopic ossification of soft tissues and cumulative disability. Methods. This is a retrospective case...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2022/9857766 |
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| author | Alexandra D. Forrest Danielle M. Vuncannon Jane E. Ellis Zvi Grunwald Frederick S. Kaplan |
| author_facet | Alexandra D. Forrest Danielle M. Vuncannon Jane E. Ellis Zvi Grunwald Frederick S. Kaplan |
| author_sort | Alexandra D. Forrest |
| collection | DOAJ |
| description | Objective. To evaluate maternal and fetal outcomes in pregnant patients with fibrodysplasia ossificans progressiva (FOP; OMIM#135100), an ultrarare genetic disorder characterized by progressive heterotopic ossification of soft tissues and cumulative disability. Methods. This is a retrospective case series of three patients with FOP who were admitted to Grady Memorial Hospital in Atlanta, Georgia, from to February 2011 to July 2021. Results. Three women delivered preterm infants at our institution. These cases posed unique anesthetic and obstetric technical challenges, particularly when securing the airway and performing cesarean delivery. Importantly, each patient received perioperative glucocorticoids for prevention of further heterotopic ossification. Conclusion. FOP is a unique clinical diagnosis encountered by obstetricians and requires multidisciplinary management for optimal outcomes. |
| format | Article |
| id | doaj-art-15bb9c60754e43b68701f459073102e3 |
| institution | Kabale University |
| issn | 2090-6692 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-15bb9c60754e43b68701f459073102e32025-02-03T05:50:36ZengWileyCase Reports in Obstetrics and Gynecology2090-66922022-01-01202210.1155/2022/9857766Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the LiteratureAlexandra D. Forrest0Danielle M. Vuncannon1Jane E. Ellis2Zvi Grunwald3Frederick S. Kaplan4Department of Gynecology and ObstetricsDepartment of Gynecology and ObstetricsDepartment of Gynecology and ObstetricsDepartment of AnesthesiologyDepartment of Orthopedic Surgery and MedicineObjective. To evaluate maternal and fetal outcomes in pregnant patients with fibrodysplasia ossificans progressiva (FOP; OMIM#135100), an ultrarare genetic disorder characterized by progressive heterotopic ossification of soft tissues and cumulative disability. Methods. This is a retrospective case series of three patients with FOP who were admitted to Grady Memorial Hospital in Atlanta, Georgia, from to February 2011 to July 2021. Results. Three women delivered preterm infants at our institution. These cases posed unique anesthetic and obstetric technical challenges, particularly when securing the airway and performing cesarean delivery. Importantly, each patient received perioperative glucocorticoids for prevention of further heterotopic ossification. Conclusion. FOP is a unique clinical diagnosis encountered by obstetricians and requires multidisciplinary management for optimal outcomes.http://dx.doi.org/10.1155/2022/9857766 |
| spellingShingle | Alexandra D. Forrest Danielle M. Vuncannon Jane E. Ellis Zvi Grunwald Frederick S. Kaplan Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature Case Reports in Obstetrics and Gynecology |
| title | Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature |
| title_full | Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature |
| title_fullStr | Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature |
| title_full_unstemmed | Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature |
| title_short | Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature |
| title_sort | fibrodysplasia ossificans progressiva and pregnancy a case series and review of the literature |
| url | http://dx.doi.org/10.1155/2022/9857766 |
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