Personal exposure to air pollutants and immune system biomarkers in pregnant women
Abstract The immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. One-week personal measurements of exposure to nitrogen dioxide (NO2), particulate matter with an aerodynamic diameter of ≤ 2.5 µm mass conc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-98712-7 |
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| author | Anouk Marsal Laurene Frau Laurence Chaperot Ines Amine Sarah Lyon-Caen Anne Boudier Jean-Luc Jaffrezo Rhabira Elazzouzi Claire Philippat Karine Supernant Johanna Lepeule Joane Quentin Ryan Chartier Sam Bayat Remy Slama Gaelle Uzu Valérie Siroux |
| author_facet | Anouk Marsal Laurene Frau Laurence Chaperot Ines Amine Sarah Lyon-Caen Anne Boudier Jean-Luc Jaffrezo Rhabira Elazzouzi Claire Philippat Karine Supernant Johanna Lepeule Joane Quentin Ryan Chartier Sam Bayat Remy Slama Gaelle Uzu Valérie Siroux |
| author_sort | Anouk Marsal |
| collection | DOAJ |
| description | Abstract The immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. One-week personal measurements of exposure to nitrogen dioxide (NO2), particulate matter with an aerodynamic diameter of ≤ 2.5 µm mass concentration (PM2.5) and PM2.5 oxidative potential (OP) were assessed in 270 pregnant women from the French cohort SEPAGES. PM filters were analyzed for PM2.5 OP using the dithiothreitol (DTT) and the ascorbic acid (AA) assays. From a blood sample withdrawn at the end of the exposure measurement week, levels of 29 cytokines and chemokines were measured at baseline and after T cell and dendritic cell activation with phytohemagglutinin (PHA) and resiquimod (R848), respectively. Associations between each air pollutant and each cytokine were assessed using adjusted linear regression models. An increase in NO2 exposure was associated with higher interleukin 10 (IL-10) and lower PHA-activated tumor necrosis factor (TNF). No association with PM2.5 concentration was observed, but increased exposure to PM $${\text{OP}}^{{{\text{AA}}}}$$ OP AA was associated with lower baseline and R848-activated IL-8 and increased exposure to PM $${\text{OP}}^{\text{DTT}}$$ OP DTT was associated with higher PHA-activated IL-17A. Our study provides insights into the relationships between air pollution exposure and immune function among pregnant women. |
| format | Article |
| id | doaj-art-15b926139b0f4ef38e2d2e1165bee667 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-15b926139b0f4ef38e2d2e1165bee6672025-08-20T03:48:15ZengNature PortfolioScientific Reports2045-23222025-05-0115111210.1038/s41598-025-98712-7Personal exposure to air pollutants and immune system biomarkers in pregnant womenAnouk Marsal0Laurene Frau1Laurence Chaperot2Ines Amine3Sarah Lyon-Caen4Anne Boudier5Jean-Luc Jaffrezo6Rhabira Elazzouzi7Claire Philippat8Karine Supernant9Johanna Lepeule10Joane Quentin11Ryan Chartier12Sam Bayat13Remy Slama14Gaelle Uzu15Valérie Siroux16University Grenoble Alpes, CNRS, INRAE, IRD, Grenoble INP, IGEUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthEFS, Recherche Et DéveloppementUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthUniversity Grenoble Alpes, CNRS, INRAE, IRD, Grenoble INP, IGEUniversity Grenoble Alpes, CNRS, INRAE, IRD, Grenoble INP, IGEUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthRTI International, Research Triangle ParkDepartment of Pulmonology and Physiology, CHU Grenoble AlpesUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthUniversity Grenoble Alpes, CNRS, INRAE, IRD, Grenoble INP, IGEUniversity Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l’Avancée des Biosciences (IAB), Team of environmental epidemiology applied to development and respiratory healthAbstract The immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. One-week personal measurements of exposure to nitrogen dioxide (NO2), particulate matter with an aerodynamic diameter of ≤ 2.5 µm mass concentration (PM2.5) and PM2.5 oxidative potential (OP) were assessed in 270 pregnant women from the French cohort SEPAGES. PM filters were analyzed for PM2.5 OP using the dithiothreitol (DTT) and the ascorbic acid (AA) assays. From a blood sample withdrawn at the end of the exposure measurement week, levels of 29 cytokines and chemokines were measured at baseline and after T cell and dendritic cell activation with phytohemagglutinin (PHA) and resiquimod (R848), respectively. Associations between each air pollutant and each cytokine were assessed using adjusted linear regression models. An increase in NO2 exposure was associated with higher interleukin 10 (IL-10) and lower PHA-activated tumor necrosis factor (TNF). No association with PM2.5 concentration was observed, but increased exposure to PM $${\text{OP}}^{{{\text{AA}}}}$$ OP AA was associated with lower baseline and R848-activated IL-8 and increased exposure to PM $${\text{OP}}^{\text{DTT}}$$ OP DTT was associated with higher PHA-activated IL-17A. Our study provides insights into the relationships between air pollution exposure and immune function among pregnant women.https://doi.org/10.1038/s41598-025-98712-7Immune systemCytokinesParticulate matterOxidative potentialNitrogen dioxidePregnancy |
| spellingShingle | Anouk Marsal Laurene Frau Laurence Chaperot Ines Amine Sarah Lyon-Caen Anne Boudier Jean-Luc Jaffrezo Rhabira Elazzouzi Claire Philippat Karine Supernant Johanna Lepeule Joane Quentin Ryan Chartier Sam Bayat Remy Slama Gaelle Uzu Valérie Siroux Personal exposure to air pollutants and immune system biomarkers in pregnant women Scientific Reports Immune system Cytokines Particulate matter Oxidative potential Nitrogen dioxide Pregnancy |
| title | Personal exposure to air pollutants and immune system biomarkers in pregnant women |
| title_full | Personal exposure to air pollutants and immune system biomarkers in pregnant women |
| title_fullStr | Personal exposure to air pollutants and immune system biomarkers in pregnant women |
| title_full_unstemmed | Personal exposure to air pollutants and immune system biomarkers in pregnant women |
| title_short | Personal exposure to air pollutants and immune system biomarkers in pregnant women |
| title_sort | personal exposure to air pollutants and immune system biomarkers in pregnant women |
| topic | Immune system Cytokines Particulate matter Oxidative potential Nitrogen dioxide Pregnancy |
| url | https://doi.org/10.1038/s41598-025-98712-7 |
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