Brain metastases from lung cancer: recent advances and novel therapeutic opportunities
Abstract Metastatic intracranial progression drastically impacts prognosis, therapeutic considerations and quality of life. The increasing incidence of lung cancer patients developing brain metastases (BM) parallels the incorporation of more effective systemic agents and improved surveillance. Our e...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Oncology |
| Online Access: | https://doi.org/10.1007/s12672-025-01873-0 |
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| _version_ | 1850087369661743104 |
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| author | Stephen C. Layng Alexis Betsock Alireza Mansouri Takefumi Komiya Joseph A. Miccio Sean S. Mahase Jonathan P. S. Knisely |
| author_facet | Stephen C. Layng Alexis Betsock Alireza Mansouri Takefumi Komiya Joseph A. Miccio Sean S. Mahase Jonathan P. S. Knisely |
| author_sort | Stephen C. Layng |
| collection | DOAJ |
| description | Abstract Metastatic intracranial progression drastically impacts prognosis, therapeutic considerations and quality of life. The increasing incidence of lung cancer patients developing brain metastases (BM) parallels the incorporation of more effective systemic agents and improved surveillance. Our evolving knowledge of BM pathophysiology, along with advancements in surgical, radiotherapy and systemic therapy options, is rapidly changing prognostication and treatment paradigms. Optimal management of BM in the modern era is patient-specific, dependent on performance status, comorbidities, intracranial and extracranial disease burden, leptomeningeal disease, and the presence of targetable mutations. The purpose of this review is to provide a detailed overview of the detection, prognostication, and multidisciplinary, management of BM arising from non-small cell lung cancer and small cell lung cancer. We discuss contemporary evidence and active clinical trials supporting a wide array of treatment options, including surgery, radiosurgery, memory-avoidance whole brain radiation, craniospinal irradiation, chemotherapy, targeted agents and immunotherapy. Multidisciplinary paradigms will continue to evolve as currently accruing randomized trials evaluating these promising treatments options mature. |
| format | Article |
| id | doaj-art-15b8329cce1a4d5c8a9f5db1e383b88b |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-15b8329cce1a4d5c8a9f5db1e383b88b2025-08-20T02:43:13ZengSpringerDiscover Oncology2730-60112025-02-0116111610.1007/s12672-025-01873-0Brain metastases from lung cancer: recent advances and novel therapeutic opportunitiesStephen C. Layng0Alexis Betsock1Alireza Mansouri2Takefumi Komiya3Joseph A. Miccio4Sean S. Mahase5Jonathan P. S. Knisely6Department of Radiation Oncology, Penn State Cancer InstituteDepartment of Radiation Oncology, Penn State Cancer InstituteDepartment of Neurosurgery, Penn State Cancer InstituteDepartment of Hematology/Oncology, Penn State Cancer InstituteDepartment of Radiation Oncology, Penn State Cancer InstituteDepartment of Radiation Oncology, Penn State Cancer InstituteDepartment of Radiation Oncology, Weill Cornell MedicineAbstract Metastatic intracranial progression drastically impacts prognosis, therapeutic considerations and quality of life. The increasing incidence of lung cancer patients developing brain metastases (BM) parallels the incorporation of more effective systemic agents and improved surveillance. Our evolving knowledge of BM pathophysiology, along with advancements in surgical, radiotherapy and systemic therapy options, is rapidly changing prognostication and treatment paradigms. Optimal management of BM in the modern era is patient-specific, dependent on performance status, comorbidities, intracranial and extracranial disease burden, leptomeningeal disease, and the presence of targetable mutations. The purpose of this review is to provide a detailed overview of the detection, prognostication, and multidisciplinary, management of BM arising from non-small cell lung cancer and small cell lung cancer. We discuss contemporary evidence and active clinical trials supporting a wide array of treatment options, including surgery, radiosurgery, memory-avoidance whole brain radiation, craniospinal irradiation, chemotherapy, targeted agents and immunotherapy. Multidisciplinary paradigms will continue to evolve as currently accruing randomized trials evaluating these promising treatments options mature.https://doi.org/10.1007/s12672-025-01873-0 |
| spellingShingle | Stephen C. Layng Alexis Betsock Alireza Mansouri Takefumi Komiya Joseph A. Miccio Sean S. Mahase Jonathan P. S. Knisely Brain metastases from lung cancer: recent advances and novel therapeutic opportunities Discover Oncology |
| title | Brain metastases from lung cancer: recent advances and novel therapeutic opportunities |
| title_full | Brain metastases from lung cancer: recent advances and novel therapeutic opportunities |
| title_fullStr | Brain metastases from lung cancer: recent advances and novel therapeutic opportunities |
| title_full_unstemmed | Brain metastases from lung cancer: recent advances and novel therapeutic opportunities |
| title_short | Brain metastases from lung cancer: recent advances and novel therapeutic opportunities |
| title_sort | brain metastases from lung cancer recent advances and novel therapeutic opportunities |
| url | https://doi.org/10.1007/s12672-025-01873-0 |
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