Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues
According to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered. In addition, 11.9 million people have impaired glucose tolerance and impaired fasting glucose levels [1]. One of the significant risk factors f...
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Endocrinology Research Centre
2014-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6769 |
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| author | Ekaterina Olegovna Koksharova Alexander Yur'evich Mayorov Marina Vladimirovna Shestakova Ivan Ivanovich Dedov |
| author_facet | Ekaterina Olegovna Koksharova Alexander Yur'evich Mayorov Marina Vladimirovna Shestakova Ivan Ivanovich Dedov |
| author_sort | Ekaterina Olegovna Koksharova |
| collection | DOAJ |
| description | According to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered. In addition, 11.9 million people have impaired glucose tolerance and impaired fasting glucose levels [1]. One of the significant risk factors for type 2 DM (T2DM) is obesity, which increases insulin resistance (IR). IR is the major pathogenetic link to T2DM. According to current concepts, there are three types of adipose tissue: white adipose tissue (WAT), brown adipose tissue (BAT) and ?beige?, of which the last two types have a thermogenic function. Some research results have revealed the main stages in the development of adipocytes; however, there is no general consensus regarding the development of ?beige? adipocytes. Furthermore, the biology of BAT and ?beige? adipose tissue is currently being intensively investigated, and some key transcription factors, signalling pathways and hormones that promote the development and activation of these tissues have been identified. The most discussed hormones are irisin and fibroblast growth factor 21, which have established positive effects on BAT and ?beige? adipose tissue with regard to carbohydrate, lipid and energy metabolism. The primary imaging techniques used to investigate BAT are PET-CT with 18F-fluorodeoxyglucose and magnetic resonance spectroscopy. With respect to the current obesity epidemic and associated diseases, including T2DM, there is a growing interest in investigating adipogenesis and the possibility of altering this process. BAT and ?beige? adipose tissue may be targets for developing drugs directed against obesity and T2DM. |
| format | Article |
| id | doaj-art-15b6445a6cb6458498fc7e33de1b994e |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-15b6445a6cb6458498fc7e33de1b994e2025-08-20T01:57:08ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782014-12-0117451510.14341/DM201445-156540Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissuesEkaterina Olegovna Koksharova0Alexander Yur'evich Mayorov1Marina Vladimirovna Shestakova2Ivan Ivanovich Dedov3Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowAccording to the International Diabetes Federation, 10.9 million people have diabetes mellitus (DM) in Russia; however, only up to 4 million are registered. In addition, 11.9 million people have impaired glucose tolerance and impaired fasting glucose levels [1]. One of the significant risk factors for type 2 DM (T2DM) is obesity, which increases insulin resistance (IR). IR is the major pathogenetic link to T2DM. According to current concepts, there are three types of adipose tissue: white adipose tissue (WAT), brown adipose tissue (BAT) and ?beige?, of which the last two types have a thermogenic function. Some research results have revealed the main stages in the development of adipocytes; however, there is no general consensus regarding the development of ?beige? adipocytes. Furthermore, the biology of BAT and ?beige? adipose tissue is currently being intensively investigated, and some key transcription factors, signalling pathways and hormones that promote the development and activation of these tissues have been identified. The most discussed hormones are irisin and fibroblast growth factor 21, which have established positive effects on BAT and ?beige? adipose tissue with regard to carbohydrate, lipid and energy metabolism. The primary imaging techniques used to investigate BAT are PET-CT with 18F-fluorodeoxyglucose and magnetic resonance spectroscopy. With respect to the current obesity epidemic and associated diseases, including T2DM, there is a growing interest in investigating adipogenesis and the possibility of altering this process. BAT and ?beige? adipose tissue may be targets for developing drugs directed against obesity and T2DM.https://www.dia-endojournals.ru/jour/article/view/6769insulin resistancetype 2 diabetesbrown adipose tissue?beige? adipose tissue |
| spellingShingle | Ekaterina Olegovna Koksharova Alexander Yur'evich Mayorov Marina Vladimirovna Shestakova Ivan Ivanovich Dedov Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues Сахарный диабет insulin resistance type 2 diabetes brown adipose tissue ?beige? adipose tissue |
| title | Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues |
| title_full | Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues |
| title_fullStr | Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues |
| title_full_unstemmed | Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues |
| title_short | Metabolic characteristics and therapeutic potential of brown and ?beige? adipose tissues |
| title_sort | metabolic characteristics and therapeutic potential of brown and beige adipose tissues |
| topic | insulin resistance type 2 diabetes brown adipose tissue ?beige? adipose tissue |
| url | https://www.dia-endojournals.ru/jour/article/view/6769 |
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